| Objects:For a long time, people think that language function was involved mainly with frontal and temporal cortex. But in these years, there were some neural system diseases caused by basal ganglia damaged, such as Parkinson's disease, hepatolenticular degeneration, Huntington chorea, primary calcification of basal ganglia, and so on, had different types of language disorder. So, the basal ganglia may have possibility to take part in the cortex language function, having highly value to research. At present, the correlated research concentrated on the competence of oral language on one side and on the question of each lobe of cerebral hemisphere how to participate written competence on the contrary. The investigation to the written competence of basal ganglia, especially the Chinese writing that had bright characteristic became the blind spot of the former two researching pathways.To analyze synthetically the correlation between the clinical behavior of the patients, the conformation and the glucose metabolism of the basal ganglia; evaluate its action on the competence of Chinese writing and investigate its the neuropsychological mechanism, which would be important in providing the theoretical evidence to discover the pathogenesis of certain diseases caused by the basal ganglia damaged, and in exploring new direction for its diagnosis andrehabilitation.Methods:1.10 cases healthy subjects, freshmen of undergraduate, ages from 18 to 24, were studied with PET selecting 18F-FDG as tracer to observe and compare the glucose metabolism of basal ganglia during pseudo-writing and characters writing.2.Basal ganglia damaged patients 41 cases were examined the competence of oral and written language and other cognitive with ABC and CAB to discern the type of language disorders and analyze their character, comparing with control: the cortex damaged patients 21 cases companion with agraphia with ABC confirming.3.Computerized image-processing technology was used to standardize and reconstruct the 2D/3D skull CT/MRI images. The results were showed directly and the relation between basal ganglia damaged and Chinese agraphia were evaluated.Results:1.During the process of characters writing, 10 health subjects showed a significant activation on the bilateral lentiform nucleus and caudate nucleus comparing with that of pseudo-writing.2.In 41 cases basal ganglia damaged, 21 cases were on the left basal ganglia, of which 19 were aphasia and agraphia. 17 cases were injured on the right basal ganglia, of which 1 were aphasia and 4 were agraphia. 3 cases were on the6bilateral basal ganglia, of which 3 were aphasia and 2 were agraphia. The morbidity difference among the left, right and bilateral was significant. The types of basal ganglia agraphia were AAg, VAg, PAg, MAg and GAg. There were significant difference in automatic writing, dictation, picture writing and spontaneous writing between basal ganglia and cortex damaged. What's more, the difference was significant in syntax, the rate of the GAg and simple words memory too.3. The image-processing results showed that agraphia lesion of basal ganglia damaged mostly on the left side: left putamen, the head and the body of the caudate. However, there was less agraphia on the right side: the lesion on the right putamen and the body of caudate nucleus.Conclusion:1-. The basal ganglia, the subcortical structure, participates the process of characters writing.2 The agraphia caused by left basal ganglia damaged, having dominant of AAg appearing semantic impairment, and the agraphia caused by right basal ganglia damaged, having dominant of VAg appearing visuospatial impairment.3 The agraphia caused by basal ganglia damaged mostly were AAg; its characters were: the difficulty informing the characters, wrong characters, sentence and text disorder.4 The agraphia caused by basal ganglia and by cortex damaged have their own characters, there being crossing and overlap between them.5The basal ganglia adjusts the formation of writing syntax to cortex. There were i... |
