Experimental Study On Therapeutic Effects Of Fengshiruyi Capsule On Rheumatoid Arthritis

Objective:To explore the therapeutic mechanism of Fengshiruyi capsule in treating rheumatoid arthritis(RA)Methods: The experimental animals were randomly divided into large dosage group, middle dosage group, small dosage group of Fengshiruyi capsule, huobahuagen tablet group, Brufen group, and water groupTo observe individually the effects of Fengshiruyi capsule on ear swelling resulted from xylene in mice and in the capillaries permeability in mice and on the paw edema induced by carrageenin in rats and on white cell migration of celiac cavity in rats have been observed individuatly The influences of Fengshiruyi capsule on granuloma induced by cotton pellets in mice and induced by croton oil in rats were observed We studied the animal model of adjuvant arthritis(AA) to observe the prevent and treatable function of Fengshiruyi capsule The effects of Fengshiruyi capsule on analgesia was studied with twisting-body caused by acetic acid and thermal-plate methods in miceThe influences of Fengshiruyi capsule on delayed-type skin hypersensitivity in mice were observedResults: Fengshiruyi capsule had obviously inhibitory effect on the swelling, the increased capillary of permeability and the migration of white cell during the process of inflammationlt could inhibit obviously the granuloma induced by cotton pellets in mice and induced by croton oil in rats Fengshiruyi capsule could inhibit obviously delayed hypersensitive reaction of DNCB to skin of mice Fengshiruyi capsule could reduce number of times of the body twisting due to pain caused by acetic acid, prolong the incubation period for the body twisting Fengshiruyi capsule had significant analgesic effect on thermal-plate induced painFengshiruyi capsule had good prevent and treatablefunction on adjuvant arthritis(AA)Conclusion: Fengshiruyi capsule has distinct anti-inflammatory and analgesic effect Fengshiruyi capsule has obviously prevent and treatable function on adjuvant arthritis(AA) Fengshiruyi capsule has good functions of regulating immune Fengshiruyi capsule could inhibit obviously delayed hypersensitive reaction to skin of micelt has a broad prospect for utilizing and developing...