Research On The Changes Of Active Vascular Factors In Arteriosclerosis Obliterans

This research aims at discussing the rule of the changes of endotheliotoxin-1 (ET-1), nitrous oxide (NO), thromboxane B2(TXB2), 6-keto-prostaglandin F1a (6-keto-PGF1a), lipid and hemorheo logical factors through clinical observation. The author has measured the above factors in 60 patients with Arteriosclerosis Obliterans (ASO) among whom 30 were attributed to the syndrome of blood stasis, and 30 were attributed to pathogenic dampness-heat attacking the lower limb according to the syndrome differentiation of Traditional Chinese Medicine and the author also has set a control group consisting of checkup takers. As the result shows, the levels of TC, TG and LDL in lipid, the levels of ET-1 and TXB2 in active vascular factors and the whole blood viscosity, erythrocyte aggregation index, plasma fibrinogen of ASO patients are higher than those of checkup takers while the HDL level in lipid, 6-Keto-PGF1a in active vascular factors and the erythrocyte transforming index are comparatively lower. Compared with patients with blood stasis, the levels of TC, TG and LDL in lipid, the levels of ET-1 and TXB2 in active vascular factors and the whole blood viscosity, erythrocyte aggregation index, plasma fibrinogen are higher than those of patients with pathogenic dampness-heat attacking the lower limb and the level of HDL in lipid, the level of 6-Keto-PGF1a?in active vascular factors and the erythrocyte transforming indexes are comparatively lower. This research proves the changes of the indexes mentioned above corresponds to the dialectical type-classifications in Traditional Chinese Medicine, reveals the rule of incidence of different type-classifications of Traditional Chinese Medicine, provides objective basis for clinical diagnosis and dialectical treatment and helps to realize the combination of macro and micro dialectics.