| [Objective]Pregnancy induced hypertension syndrome (PIH) is special disease in gestation. And it seriously threatens the mother and fetal lives, can cause long-dated sequela. In 1988 the Epidemical investigation of 25 provinces and cities of our country, showed that 9.4% pregnant women taking place of different degree PIH. Often being taken bad after 20 weeks in gestation, PIH is one of the main reasons to cause the death of the maternity and fetus. Clinical findings of PIH is high blood pressure,proteinuria, edema, when it is serious appearing to have tic,coma, even the death of mother and fetal. By the retrospective study of clinical and laboratory data of the 137 patients with PIH and 53 normal pregnant women, this text investigates the changes and significances of biochemical indexes of the different degree PIH to improve the accurate rate of the clinical diagnosis, dynamically monitor the development of the disease and improve the mother and infant prognosis. [Data and methods] It chooses 137 patients with PIH and 53 normal pregnant women without complications from the patients of my hospital in 1999 January ～ 2003 December. It chooses 46 cases of mild PIH, 42 cases of moderate PIH, 49 cases of serious PIH (37 cases of preeclampsia, 12 cases of eclampsia). The gestation weeks distinguishes to 28-42, 38-41 weeks, the age is 20-38 and 21-27 years old. All the pregnant women have no chronic high blood pressure and chronic liver, kidney disease history, everyone is primipara. The PIH diagnosis standards are according to the 5' edition 《 Obstetrics and Gynecology Science 》 of whole country high medicine college. The diagnosis standards of abnormal liver function are: ALT>0 U/l or DBIL>.0 umol/ or ALB< 35 g/l. This research is divided into 5 groups:1, control: 53 normal pregnant women without complications ;2, 46 cases of mild PIH; 3,42 cases of moderate PIH; 4, 37 cases of preeclampsia; 5,12 cases of eclampsia. The inpatients accept regularly B-ultrasound, blood routine test, urine routine test, liver function test, kidney function test, serum electrolytes. It uses the SPSS statistics software to analyze the data. Two group comparing uses t test, and all data figure with x ± s; Percentage comparing uses χ2 test. P<0.05 is used as the marked differentia. [Result]The changes of serological indexes in PIH are significant decrease of HGB and PLT, and marked increase of HCT and MPV, comparing with the normal pregnant women.The changes of liver function indexes in PIH comparing with the normal pregnant women is significant decrease of TP and ALB, and marked increase of ALT, AST, ALP, GGT, TBIL, DBIL, TBA, FN . The changes of kidney function indexes in PIH comparing with the normal pregnant women is significant increase of BUN, CRE, UA .The disorder of serum electrolytes indexes in PIH comparing with the normal pregnant women is significant decrease of Ca2+ and CLˉ, and increase of K+, P, Mg2+. Na+ behaves slightly lower. Since a majority of inpatients accepted the treatment of magnesium phosphate, the statistic result of Mg2+ invalid.The abnormal liver function in PIH increases the rate of premature labor. Terminating the gestation early, is the common method in clinical to handle with the abnormal liver function in PIH. The HCT going up, the PLT reducing and the UA going up can cause unfavorable perinatal prognosis of maternity and fetus. When both of urine protein and blood pressure increase, the incidence of unfavorable perinatal fetal prognosis is increased.[Conclusion]The changes of biochemical indexes in PIH obviously change with the progressive severity of the state of the illness. It indicates obvious blood concentration,liver and kidney function impairing,disorder of serum electrolytes. HGB, PLT, TP, ALB, Ca2+, the CLˉ decrease obviously, HCT, MPV, ALT, AST, ALP, GGT, TBIL, DBIL, TBA, FN, BUN, CRE, UA, K+ and P increases obviously.When we diagnose the PIH, we should pay attention to changes of biochemical indexes as important as our country curr... |
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