The Relationship Between Routine Biochemical Examinations And Child-Pugh Score In 174 Patients With Cirrhosis

The relationship between routine biochemical examinationand Child-Pugh Score in 174 patients with cirrhosis Cirrhosis of liver is a kind of common chronic disease. The patients usually suffer from it for a long time. According to the report of WTO in 1987, there are about 17.1 thousand of persons suffer from it among 100 thousand of patients. There are too many people died of it .So it is very important to evaluate the patients' liver functions and prognosis. Now there is a criterion which is consisted of ALB, PT, TIBL, Hepatic coma and ascide to estimate liver function .The most doctors consent to it. But the criterion can be affected by many factors, it is necessary to find other standards to help us to evaluate liver function of the patients of cirrhosis. We collected the dates of 211 patients in China-Japan United Hospital between September 2002-September 2003.One hundred and seventy four patients with liver cirrhosis were divided into three groups : Child-Pugh A(53), Child-Pugh B(72), Child-Pugh C(49), according to Child-Pugh Score classification. Fifty-five patients without liver disease were as the controls. The liver functions and electrolytes were tested by autoanalysers from company named Beckman in America. The result of them was analyzed respectively. We want to find the relationship between Child-Pugh Score of cirrhosis and routine biochemistry tests.Results 1 the concentration of serum calcium in patients with liver cirrhosis was lower significantly than that in control group (P<0.01). Furthermore the decrease of serum calcium was observed and there was significantly difference between Child-Pugh C Child-Pugh A and Child-Pugh B (P<0.01).The sensitivity of serum calcium in the patients of cirrhosis is 67.8%, and is similar to that of TBIL and ALB. 2 To compared with the control group that the serum total bile acids level of cirrhosis group were significantly higher (ï¼°<0.01).With the progression of impairment of liver function, the level of serum total bile acids increased gradually in patients of cirrhosis of liver. There was a significant difference among each class (ï¼°<0.01). The sensitivity of TBA was 82.8%, and it was higher than that of routine liver function tests .3 the concentration of serum CHE in patients with liver cirrhosis was lower significantly than that in control group (P<0.01).There was a significant difference among each class (P<0.01). Conclusions serum TBA, electrolytes especially Ca2+ and CHE are sensitive biochemical parameters in evaluating hepatic functions of cirrhotic patients. We can assess liver function of cirrhosis patients through them. They are sensitive index to reflect the damage of the liver and to reflect the serious degree of the disease.