The Relationship Of Plasma Leptin And C-Reactive Protein With Type 2 Diabetes

Objective To investigate the association of leptin, c-reactive protein, obesity, serum lipid levels and insulin resistance. To assess the relationship between leptin, CRP and type 2 diabetes. Methods Sixty-six subjects who had type 2 diabetes were divided into two groups according to body mass index(BMI):non-obese group and obese group. Sixty-seven subjects who didn't have diabetes were divided into two groups, too. Their weight, height, waist and hip circumferences, fat% were measured. Total triglycerides, cholesterol, high density lipoprotein-cholesterol, low density lipoprotein- cholesterol, C-reactive protein, fasting plasma glucose, insulin and leptin were also measured. All parameters were analyzed by SPSS 10.0 software. Results (1) Fasting serum leptin,CRP,TG, VLDLC, HOMA-IR and -ISI in type 2 diabetes were higher than non-diabetes, P<0.05; Plasma leptin, CRP and HOMA-IR in obesity were higher than non-obesity, P<0.05; (2)Leptin was correlated with sex, fat% in every groups, was correlated with ISI in males and females, was correlated with sex, fat% ,HOMA-IR, ISI and fasting insulin in all samples; CRP was correlated with BMI and ISI; (3)Leptin was correlated with fat%,HOMA-IR and ISI; HOMA-IR and ISI were correlated with fat%,BMI and leptin; fat% was correlated with leptin,HOMA-IR and ISI; (4)HOMA-IR (OR=106.696), Leptin (OR=6.863), CRP (OR=6.239) and TG (OR=6.923) were significant risk factors for type 2 diabetes. Conclusion (1)Leptin and CRP were significant risk factors for insulin resistance and type 2 diabetes; (2)Fat% and BMI were strongly correlated with insulin resistance and type 2 diabetes.