| Periodontal pathogens and bacterial components in periodontal tissue trigger local inflammatory process and low levels of bacteremia, LPS and other bacteria! components may provide stimuli for the increase of levels of some systemic inflammatory remarks. Thus some inflammatory mediators which cause destruction of periodontal connective tissue and alveolar bone may stimulate a series of reactions and then affect systemic organs.Coronary heart disease (CHD) is a multi-factorial inflammatory disease. Based on a lot of epidemiologic studies and molecular biologystudies, homocysteine and C-Reactive Protein(CRP) and other systemic markers for CHD have been accepted by many learners as new risks.Reports on the correlation between periodontal infection and CHDare not scarce: some learners found alveolar bone absorption in patients of atherosclerosis(non-diabetes) was much more severe than healthy controls; they made further studies and found periodontitis was a risk factor for CHD which was independent of age, triglyceride, total cholesterol, hypertension, diabetes and smoking.Our objectives were to find out that: (1) whether the severity of periodontitis was correlated to the serum level of HCY and that of CRP; (2) if the severity of periodontitis was correlated to the serum level of HCY and that of CRP, how could periodontal parameters demonstrate the relationship of the severity of periodontitis and the serum level of HCY and that of CRP? In order to solve the problems mentioned above, we dectected serum levels of HCY, CRP, triglyceride, total cholesterol in subjects of periodontitis and non-periodontitis and made full periodontal examination, then analysed all data we have gotten in the research.Materials and methods1. Selected 60 study subjects (including patients of periodontitis and periodontally healthy people): the median age is 35 (from 16 to 60); 32 males and 28 females; all were free of systemic disease and hadn't taken antibiotics in the past three months; kept them informed about our study all along. 2. Recorded general information: gender, age, BMI, education, smokingand drinking.3. Made full periodontal examination and recorded all periodontal parameters: PLI, BI, PD, AL, sulfide, total teeth, etc .4. Detected serum levels of HCY, CRP, Triglyceride, total cholesterol.5. Made statistical analysis: dividing all subjects into three groups according to Al(AL 2mm, 2mm3mm) and analysing the difference of serum levels of HCY and CRP among three groups; assessing the relations between periodontal parameters and HCY,CRP by Spearman's rank correlation; employing two general linear models to evaluate the significant contribution of periodontal parameters interactions to HCY and CRP.Results1.There were 18 subjects with high AL(AL =5.30 1.38), 25 with moderate AL(AL =2.39 0. 34) and 17 periodontally healthy controls(AL=1.55 0.33). Statistical differences of periodontal parameters among three groups had been seen: PD of group with high AL was significantly higher than other two groups(5.76 1.80 Vs 3.19 1.30. 3.37 0. 83; F= 22.214, P=0.000); sulfide of group with high AL was significantly higher than other two groups ( 53.556 18.714Vs 26.618 20.149, 32.800 14.830; F=l 1.579, P =0.000) ; and so was the case of PLI and BI.(F=16.504, P =0.000; F=16.504, P =0.000)2.Mean serum level of HCY in subjects with high levels of mean clinicalattachment loss was significantly higher than that in others (8.82 2.80, 11.43 1.81, 20.35 4.10, F=77.102, P=0.000)3.Mean serum level of CRP in subjects with high levels of mean clinical attachment loss was significantly higher than that in others (1.66 0. 74, 3.044 0.494, 7.124 2.614, F=56.743, P=0.000) .4.The relations between periodontal parameters and general information with HCY were assessed by Spearman's rank correlation. HCY had positive correlation with Al, PLI, BI, PD, sulfide (P<0.05) but no correlation with age, gender, education, triglyceride, total cholesterol and BMI (P>0.05...
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