High Frequence Ultrasound Scan Used In Observing The Herpes Zoster Patients' Pathological Changes Of Their Skin And Skin Nerves

Objective : To study the feasibility of using high frequence ultrasound scan to show skin and skin nerves ; To study the accuracy of using high frequence ultrasound to measure each layer of skin and skin nerves ; To observe the changes of image features of high frequence ultrasound , which is caused by the pathology-anatomy changes in the local skin or peripheral nerves ; In order to provide the base for studying the image changes of herpes zoster ; Further more it provides image base for early diagnosis and reducing the percentage of misdiagnosing . Methods : The experiment was divided into two parts-animal experimental part and clinical one . In the animal experimental part ,10 slices of skin (together with meat) from the chest of five pigs which had been just killed were examined with high frequence ultrasound . Each layer of the skin had been signed with needles separately before and after their analysis . They were also contrasted with whole specimen and the histological examination in order to test the feasibility of the method and to confirm the features of ultrasound images in normal skin , subcutaneous tissue and skinnerves . In the clinical experiment, 37 cases of herpes zoster patients with 77 pathological changes were examined , 7 cases of sequence of neuralgia with 17 pathological changes . They were all compared with the healthy side of the same patient .We observed the thickness of the skin and subcutaneous tissue , the echoing feature and the width of the skin nerves . Results : The image of the structure of skin and skin nerves showed by high frequence ultrasound corresponded with whole specimen and its histological examination exactly . The image that showed the thickness of skin and subcutaneous tissue , the diameters of skin nerves as well as the measurement of the whole specimen had no statistic discrepancy ( P>0.05) . On one hand , the skin and subcutaneous tissue of the herpes zoster patients became thicker (P<0.01),but the ones of the patients who have sequel to neuralgia changed little (P>0.05) . Both of their nerves were widen (P<0.01) . The line structure were all vague . On the other hand , the echo of the nerves is former one was lower , but the latter one's was stronger . Conclusion : The high frequence ultrasound scan can identify the structure of skin ,subcutaneous tissue and skin nerves exactly .The usage is simple and accurate . At the same time , the highfrequence ultrasound scan can show the inflammatory pathological image of the skin , skin nerves of herpes zoster patients objectively .