| Objective: To observe the protective effects of QingGuangAn Granule(QGAG) on optic nerve axons and retinal ganglion cells in rabbit eyes with acute ocular hypertension. Method : 48 rabbits were divided into two groups ( 24 in each). The acute ocular hypertension(60mmHg) models were established by forcing perfusion of normal saline solution into the anterior chamber maintained for 2h in one eye, the other eye in experimental group which was maintained at basic intraocular pressure by the same method was regard as normal control. Each group was irrigated into the stomach for 14 days. The levels of the glutamic acid and NO in retina was measured on 7 and 14 days respectively , and the pathologic changes were observed. Result: After 7 days, the glutamic acid and NO levels have significantly difference between each group (P<0.01), and the treatment group and experimental group were significantly higher than those in normal control group(P<0.05,P<0.01). But the treatment group was significantly lower than those in experimental group(P<0.01). After 14 days, the glutamic acid, and NO levels in treatment group were near to the normal control group(P>0.05). However in the experimental group was significantly higher than those in normal control group (P<0.05,P<0.01). It has significantly different between two weeks in the treatment group and experimental group (P<0.05). Electron microscope result indicated that compared with experimental group optic nerve axons swelled relatively gentler, mitochondria in optic nerve axons was clear and more , and the degree of damaged retina ganglion cells in treatment group was lesser than that in experimental group. Conclusion: QGAG can ameliorate retina microcirculation, promote the axoplasmictransport of optic nerve , accelerate NO and glutaminic acid remove in rabbits retina with acute ocular hypertension. It has the protective function for the optic nerve axons and the retinal ganglion cells. |
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