| Objective: To search for a locating-material and method guided by CT which can help localize and resect nonpalpable and invisible small pulmonary lesions, such as solitary pulmonary nodule(SPN), ground glass opacity(GGO),either in thoracooperation or fluoroscopy-assisted thoracoscopic resection. Materials and Methods: Powdered agar was dissolved in distilled water at concentrations of 2%, 3%, 5% and kept at >500C to maintain its liquid form. So did gelatin at concentration of 20%. Every material above mixed with contrast media or methylene blue and 0.5ml of mixture was injected into lung of rabbits respectively before liquid form became a hard gel. In addition, one rapid adhesive product, otologic and craniocerebral glue, which called 508, also was injected into lung of rabbit 0.5ml. Results: Gelatin, 2% agar and 3% agar could not form hard enough palpable nodules for some of them disappeared in the lung. 5% agar could be detected as a hard nodule by manual palpation and is visible under fluoroscopy for it contained barium sulfate. Moreover, pathologic exam showed that it was harmless to the lung parenchyma around. Cough arosed after injected 508 glue for it was a stimulant to respiratory airway and the whole apart of the lung injected became hard but not become a hard nodule. Conclusion: 5% agar mixed with barium sulfate marking may represent a feasible alternative technique either in thoracooperation or fluoroscopy-assisted thoracoscopic resection for localizing ncnpalpable occult lesions located away from the pleural surface.
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