| Sudden deafness is a common disease isolated or associated to vertiginous episodes. Owing to the inaccessibility of inner ear structures , they are usually without obvious cause, and little is known of their physiopathology. Several studies have shown scarce evidence supporting the role of vascular disorders, viral infections or allergic reactions. There has been no treatment proved effective for sudden deafness , even though many drugs have been used, including vasodilators, anticoagulants , plasma expanders , etc . Recently, laboratory tests have developed to explore the immune-related inflammations as a potential etiology for hearing loss.Objective: 1. to study peripheral blood T lymplhocytes subset and serum immunoglobulin in a group of patients with sudden deafness , in order to find the relationship between sudden deafness and immune system; 2.to observe the recovery rate and the immunologic alterations in patients with sudden deafness by treating them on conventional therapy and steroid therapy.MethodsiThe experimental methods includes two procedures.Procedure one : according to the criteria of The Shanghai Conference ,53 patients with sudden deafness ( men 29, women 24; mean age,39?15 ) were studied. The average number of days that elapsed from the onset of hearingloss to initial examination was 6.2 + 3.3; the patients of hemianacusia were 57 , the patients of bilateral were 6 ; 21 patients complained of rotatory vertigo ; 17 patients showed hearing loss less than 60 dBHL, 26 patients showed hearing loss more than 60 dBHL , 10 patients showed total deafness ; the average hearing loss(pure tone average,PTA) was 80 + 25 dBHL. The peripheral blood T lymplhocytes subset and serum immunoglobulin of these patients were examined by means of nephelometric methods and indirect immunofluorescence assay, compared with the control of 14 cases's( men 8, women 6; mean age,38 +15).Procedure two: patients of immunological normalities and immunological abnormalities were divided into 2 groups . Group NC: 10 patients of immunological normalities were treated by conventional therapy. Average age was 42+10 ; an interval were 5.9 + 2.8 days since the onset of hearing loss, 8 patients were examined at 1 to 7 days after onset and 2 patients were examined at 7 to 12 days after onset; the patients of hemianacusia were 8 and the patients of bilateral were 2 ; 1 patient complained of rotatory vertigo ; 2 patients showed hearing loss less than 60 dBHL, 6 patients showed hearing loss more than 60 dBHL , 2 patients showed total deafness ; the average hearing loss(PTA) was 82 + 22 dBHL; 2 patients accompanied with hypertension. Group NS: 11 patients of immunological normalities were treated by both conventional therapy and steroid therapy . Average age was 33 + 13 ; an interval were 7.0 + 3.1 days since the onset of heACing loss, 7 patients were examined at 1 to 7 days after onset and 4 patients were examined at 7 to 12 days after onset; the patients of hemianacusia were 9 , the patients of bilateral were 2 ; 5 patients complained of rotatory vertigo ; 4 patients showed heACing loss less than 60 dBHL, 6 patients showed hearing loss more than 60 dBHL , 1 patients showed total deafness ; the average hearing loss was 76 + 24 dBHL; 2 patients accompanied with hypertension. Group AC: 8 patients of immunological abnormalities were treated by conventional therapy. Average age was 47 + 15; an interval were 5.4 + 3.5 days since the onset of hearing loss;-, 2 patients were examined at 1 to 7 days after onset and 6 patients were examined at 7 to 12 days after onset; the patients of hemianacusia were 6 , thepatients of bilateral deafness were 2 ; 3 patients complained of rotatory vertigo ; 3 patients showed hearing loss less than 60 dBHL, 5 patients showed hearing loss more than 60 dBHL , no patient showed total deafness ; the average hearing loss(PTA) was 77 + 17 dBHL; 3 patients accompanied with hypertension. Group AS: 24 patients of immunological abnormalities were treated by conventional therapy and steroid ther... |
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