HLA-DR Genotyping Analysis Associated With Streptococcus Of Psoriatic Vulgaris Patients In Yunnan Han Nationality

[objective] In order to study the association between HLA-DR alleles polymorphism and susceptibility of psoriatic vulgaris patients in Yunnan Han nationality, at the same time to study the association between HLA-DR alleles polymorphism and susceptibility of psoriatic patients Associated with Streptococcus, find the susceptible gene, study whether or not the HLA-DR alleles modulating the immune response can affect the onset and clinical situation in psoriatic patients after streptococcal infection, explore the immunological and genetic pathogenesis and the molecul basis of genetics in psoriasis with streptococcal infection, [methods] 30 psoriatic vulgaris patients with non-pathogenic streptococcus and 39 normal controls in Yunnan Han nationality were examined for HLA-DR genotyping analysis by polymerase chain reaction with sequence specific primers (PCR-SSP). The historical date of 36 psoriatic patients withpathogenic streptococcal infection was compared, too. The susceptible gene was found through calculating the RR of alleles.[results] The HLA-DR7 gene frequence of the whole patients in Yunnan Han nationality was substantially increased (28.79%: 6.41%, Pc=0. 000<0. 05, RR=9. 229). The HLA-DR7 gene frequence was compared among the patients with non-pathogenic streptococcus, normal controls and the patients with pathogenic streptococcal infection respectively. There were significant differences found ( (20.00%: 6.41%: 36.11%, all P <0.0125, all RR >3.0) , the relative risk is high. The HLA-DR7 gene was susceptible gene of psoriatic vulgaris patients in Yunnan Han nationality, and may be susceptible gene of psoriatic vulgaris patients with streptococcal infection especially.[conclusion] The HLA-DR7 gene is associated with psoriatic vulgaris patients in Yunnan Han nationality and result in the susceptibility to psoriasis, which may be the common susceptible gene of psoriatic patients regardless of nation and group. The HLA-DR7 gene may be susceptible gene of psoriatic vulgaris patients with streptococcal infection especially. The immunogenetic mechanism may participate in the pathogenesis of psoriasis related to streptococcal infection.