The Reasonable Apply Of Antibiotic During The Period Of Chronic Nasosinusitis Operation

Chronic nasosinusitis is a kind of common and frequently-occuring disease in the field of nasal endoscope surgery. It results from various factors. And its pathophysiology core is nasal sinuses straitness and block, and also the barrier of the eliminating function in the mucous membrane cilia. The infection of bacillus is also an important aspect in this disease. Therefore, effects of sensitive antibiotic should not be neglected to the recovering of the rhinal film function, and to the improvement of the cilia clearance retio. This research summarized common pathogenic bacillus and filtrated sensitive antibiotics, in terms of the bacillus cultivating and medicaments sensitivity tests from the secretion of the nasal and sinus cavitywhen chronic nasosinusitis. And then indicated the antibiotic cure during the period of nasal endoscope operation, and discussed the clinical applied value of preventive administration by the research.Testing Procedures: Gather the secretions of the nasal and sinus cavity when chronic nasosinusitis, total 64 cases, carry on the bacterial culture and drugsensitive tests, extract the pathogenic bacillus, filtrate sensitive antibiotics. And select 30 cases in chronic nasosinusitis of type 1, and 48 cases of type 2, total 78 cases, allocate them randomly to test and contrast groups, following the stochastic principle, 39 cases per group. Before operation apply preventively chloric lincomycin on the test group, i.v total dosage of 4.2g; and not any medicine before operation on the contrast group, while apply chloric lincomycin after operation, last 7 days, i.v total dosage of 8.4g. In order to eliminate influences of farraginous factors, uniform interpose steps should be exerted on these two groups. And according to the symptoms and endoscope checks after 7 days of operation, carry on the statistic analysis, and discuss the clinical appliedvalue of preventive administration.Results: Total extracted 75 bacterial trunks from the secretions of the nasal and sinus cavity when chronic nasosinusitis: 23 staphylococcus epidermidis trunks, 11 cor-ten steel staphylococci trunks, 8 flu hemophilus trunks, 7 pneumococcus trunks, and 17 other aerobes trunks and 9 anaerobe trunks. And chloric lincomycin & penicillin were sensitive to almost all that bacillus, chloric lincomycin was sensitive to 49 trunks, penicillin was sensitive to 36 trunks, and both to 24 trunks. What's more, there existed statistic difference between chloric lincomycin and penicillin by chi-square test, while chloric lincomycin had a higher sensitivity. Finally, statistic significance between their statistic difference had not been found, in terms of the judges of symptoms and physical signs of 7 days after operation to the test and contrast groups (total 78 cases), which were allocated randomly, by the fourfold table definite stochastic method.Conclusions: Chronic nasosinusitis results from various factors, the infect of bacillus is an important aspect in thisdisease. Effective antibiotic cure can promote the recovering of the rhinal film function. After the diagnosis of chronic nasosinusitis has been established, pathogenic bacillus and sensitive antibiotics should be defmited, and in these cases staphylococci was the major pathogenic bacillus. And chloric lincomycin was sensitive to most of the pathogenic bacillus. Therefore, chloric lincomycin should be chosen in the antiphlogistic cure, before pathogenic bacillus were definited. Systemic and normative operation may improve the rate of curability. And reasonable preventive administration before operation may reduce the dosage of antibiotics, so as to reduce the adverse reactions, and relief the economical burden of the pateients. Therefore, it is actually provided with definite clinical applied value and social and economical benefits.