A Comparison Of The Efficacy Of Continuous Administration Using Minipump And Fractional Administration Of Antibiotic In Treating Lower Respiratory Tract Bacterial Infections

Objective:To Compare of the efficacy of continuous administration using minipump and fractional administration of time dependence antibiotic in treating lower respiratory tract bacterial infections Methods:A total of 120 cases with lower respiratory tract bacterial infections were studied in ICU from Jan.2007.1 to Jan.2010.1, a prospective randomized controlled clinical trial was conducted.120 patients were randomly divided into two groups; experimental group with 60 cases,4.5g Piperacillin/tazobactam were given by continuous administration using minip- ump, 10.0mg each an hour; total 13.5g in 24 hours; control group with 60 cases; 4.5g Piperacillin/tazobactam were given by fractional administration, one time each 8 hours; total 13.5g in 24 hours for 3 to 10 days. Result:. The cure rate of experimental group and control group were 85% and 56%, clinical efficacy rate were 95% and 86%; two groups were significantly different (P=0.000); and bacterial clearance were 96.0% and 79.4%, respectively; significantly different (P<0.05); The equal courses of treatment were5.1±0.9d in experimental group, while 7.7±1.4d of control group; significantly different (P=0.019); The equal days in hospital were 10.9±1.7d in experimental group, while7.1±1.5d of control group; significantly different (P=0.012); There was no statistical difference between two groups of effect Conclusion:The continuous administration using minipump of piperacillin/tazobactam is preferable compared with traditional fractional administration of it in the treatment of lower respiratory tract bacterial infections, and acquiring better clinical efficacy.