| The occurrence and progression of nodular goiter and thyroid adenoma, two of common thyroid diseases, have close relations with age, sex, iodine intake, living environment, inheritance and so on. The first part of present study was designed to statistically analyze the clinico-pathologic data of patients with nodular goiter and thyroid adenoma taken from files of Department of Pathology (1978-2002) in General Hospital, Tianjin Medical University, with Run test, Cox梥tuart test, ANOVA, t or t' test and Chi梥quare test. We observed the changes in biopsy ratios, proportions, mean ages, sex rates and coexisting lesions of nodular goiter and thyroid adenoma before and after iodine prophylaxis and offered statistical data of pathology for further exploration of their pathogenesis and the relationship between iodine and the two diseases and clinical diagnosis and therapy of these diseases.Because of its simple, economy, safety, validity, little complications, fine-needle aspirates biopsy (FNA) of the thyroid has been regarded as one referenced method of preoperative evaluation of thyroid lesions, distinction malignant. Combined with clinical features, it may provide correct diagnosis for most thyroid diseases. In the second part of present study, we observed the cytopathologic characteristics of FNA performed in the years of 1996-2002 in Department of Pathology in General Hospital, Tianjin Medical University, and in the years of 1998-2002 in Department of Pathology in Huanghe Hospital. We analysed the proportions, mean ages, sex rates of the thyroid diseases diagnosed by FNA with ANOVA, t or t' test and Chi-square test, and compared the results of the two partsof present study. This part of study is designed to explore the application of FNA in clinical diagnosis and the incidence of thyroid diseases.Results were as following:1. The biopsy numbers of total thyroid diseases, nodular goiter, thyroid adenoma in the twenty梖ive years were 551% 2820, 1264 respectively. The average biopsy ratios of total thyroid diseases, nodular goiter and thyroid adenoma were 2. 60%, 1. 33%, 0. 60% respectively. Biopsy ratio of thyroid diseases in total showed a descending tendency from 1982 and an ascending tendency from 1995. Biopsy ratio and proportion of nodular goiter showed an ascending tendency while thyroid adenoma showed a descending tendency during the twenty-five years. Mean age of total and female patients with the two diseases showed an ascending tendency during the twenty梖ive years. Mean age of nodular goiter was higher than thyroid adenoma. Mean age of male patients with the two diseases was higher than female patients. Adenomatous hyperplasia and papillary hyperplasia were seen earlier in female patients with nodular goiter, occult carcinoma and hyperthyroidism were seen earlier in male patients with goiter nodular. Difference was not significant in sex rate between nodular goiter and thyroid adenoma (both were 1:3-4) in the twenty-five years. Rise was found in proportion of hyperthyroidism in nodular goiter coexisting papillary hyperplasia or occult carcinoma.2. The FNA cytopathologic characteristics of thyroid diseases were various. The total number of thyroid FNA in Huanghe Hospital was 676(average 135/ year). The total number of thyroid FNA in the GeneralHospital was 222 (average 32/year). Chronic lymphocytic thyroiditis was the most common diagnosis of thyroid FNA. The proportions of nodular goiter and thyroid adenoma in thyroid operations were higher than those in FNAs. The average age of clinical hyperthyroidism was lower than Chronic lymphocytic thyroiditis. Nodular goiter and thyroid adenoma diagnosed by FNA had no significant difference in average ages. The highest average age was in patients with malignant tumor. The average age of thyroid adenoma performed FNA were higher than those performed operations. The average age of nodular goiter performed FNA in the two hospital was not different from those performed operations. Female patients with thyroid diseases were more than male patients. |
PDF Full Text Request