| Objective: To reveal, by monitoring of qEEG, the effects of different dose naloxone on acute moderate and severe head injuries.Methods:82 patients with acute moderate and severe head injuries (Glasgow Coma Scale 3-12, within 12 hours after injury) were selected for this study. According to the severity of injury, all patients were classified into three groups: GCS3～5, GCS6～8 and GCS9～12. Patients of each group were then randomly assigned to treatment with naloxone or control. In naloxone groups, low doses of naloxone (1.2mg for one minute intravenously, followed by a 24-hour infusion of 4.8mg or constant infusion of 4.8mg/d) and high doses of naloxone (2mg/2min, followed by a 24-hour infusion of 0.3/kg) were administered respectively to the patients with acutebrain injury with different severity for three days. Relative power of δ frequency and absolute power of 1-25 frequency were monitored with qEEG before and 0,10,30 minutes,1,2,24,48,72 hours after administration.Results: In GCS 9 to 12 group, relative power ofδfrequency and absolute power of 1-25 frequency were significantly different (P<0.05) in qEEG between naloxone groups and control group, while there was no significantly different of all parameters between low-dose and high-dose naloxone groups(P>0.05).In GCS 6 to 8 group, the two parameters were improved significantly in naloxone groups and were significantly different between low-dose and high-dose naloxone groups. In GCS 3 to 5 group, all parameters were not significantly different between naloxone group and control group.Conclusions: These results suggest that treatment with naloxone in patients with GCS of 6 to 12 is beneficial in terms of improved qEEG and there is not significant difference in low-dose and high-dose naloxone in GCS 9 to 12 group, but in GCS 6 to 8 group high-dose naloxone is better than low-dose naloxone. However, in GCS 3 to 5 group, high-dose naloxone may not be so effective.
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