Serum Leptin Level And Body Fat Distribution In Obstructive Sleep Apnea Hypopnea Syndrome Patients

Objective: 1.To investigate the change of fasting serum leptin level and the characteristic of body fat distribution in obstructive sleep apnea hypopnea syndrome (OSAHS). 2.To study the relationship between the change of serum leptin concentration and body fat distribution in OSAHS patients. 3.To explore the role of serum leptin and body fat distribution on the occurrence of OSAHS.Methods: Neck circumference,waist circumference,hip girth and fasting serum leptin level were measured and calculated body mass index (BMI),waist/hip ratio(WHR) and percentage of body fat in 50 men with OSAHS and 50 men with non-OSAHS .There were 30 overweight (BMI≥25 kg/m2) and 20 lean (BMI<25 kg/m2) in each group. Every OSAHS patient was observed with polysomnoguaphy (PSG) during 7 hours in whole night. The venous blood samples were obtained in the next morning in the fasting. The serum leptin concentrations were measured by ELISA. Serum leptin and body fat distribution were compared between the OSAHS subjects and non-OSAHS subjects when age,sex,BMI were takeninto account. And To analyze the correlation between the serum leptin concentration and the relational parameters in OSAHS patientsResults: 1.Compared with control subjects with a similar BMI,age,sex but without OSAHS, the OSAHS group had a significant higher circulating leptin levels(obese groups: 18.72±7.45 ng/ml vs 14.96±8.39 ng/ml p＜0.01; non-obese groups 8.09±3.87 ng/ml vs 6.15±2.75 ng/ml p＜0.01). The higher AHI, the higher serum leptin level. 2.Compared with control subjects with a similar BMI,age,sex but without OSAHS, the OSAHS group had a significant higher neck circumference(obese groups: 42.75±2.08cm vs 40.92±2.02cm p＜0.01; non-obese groups: 40.13±2.08cm vs 38.65±2.09cm p＜0.05),waist circumference (obese groups: 105.67±7.49cm vs 98.57±4.92cm p＜0.01; non-obese groups: 96.40±5.58cm vs 92.05±7.41cm p＜0.05), and waist/hip ratio (obese groups: 0.96±0.05 vs 0.93±0.04 p＜0.05; non-obese groups: 0.93±0.04 vs 0.89±0.03 p＜0.01). But the percentage of body fat was similar in OSAHS subjects and control subjects. 3. Serum leptin levels correlated positively with AHI,microarousal index,the longest apnea/hypopnea time, and correlated adversely with the lowest oxygen desaturation in all OSAHS patients. Serum leptin level correlated positively with neck circumference,waist circumference and waist/hip ratio separately. But theserum leptin level did not correlate with the percentage of body fat in overweight group and in lean group.Conclusion: Despite controlling for age,sex, BMI, the OSAHS subjects showed distinct profiles with serum leptin level and the characteristic of body fat distribution. Hyperleptinmia and over accumulation of neck and visceral fat was present in the OSAHS subjects. We conclude that there was a strong independent association with the serum leptin level and the characteristic of body fat distribution in OSAHS patients, which may play an important pole in the occurrence of OSAHS .