Study Of Serum Leptin, Insulin And Tumor Necrosis Factor-α Level, And Relationship Between Them In Patients With Obstructive Sleep Apnea

Obstructive sleep apnea syndrome ( OSAS) is one of diseases that often encountered in clinic, its'cause and pathogenic mechanism are complicated, have not been cleaning. Because of repeated hypoxyemia and disturbance of sleep-composition in sleeping, there are able to be higher incidence of cardiovascular, pulmonary vascular and cerebral vascular diseases in patients with OSAS, and lives of patients severly influenced by sleep disorder, hypomnesis and sleepy habit in day that appeared in OSAS. Through former studies, it was confirmed that obesity was one of dangerouse factors on onset of OSAS. Obesity is able to hasten the onset of OSAS, to accelerate it. What mechanism is obesity able to influence OSAS through? It had been known that leptin, insulin and tumor necrosis factor-a ( TNF-a) were closely reladve with body condition of nutrition and there were relationship between them in normal human body, some of their actions were similar and serum levels of them would bring about definite change in obese body. Other hand OSAS would be often occurred in obese men. What relationship dose exists between them in OSAS patients? There were rare studies of this aspect at present, so we studied of serum levels of leptin, insulin and TNF-a, and relationship between them in patients with OSAS.1. Study of serum leptin level in patients with obstructive sleep apneaObjective: To explore the change of serum leptin in patients with obstructive sleep apnea syndrome ( OSAS ). Method: Polysomnography was performed in 58 patients with OSAS and in 21 simple obese controls that there were notdifferences in age and body mass index (BMI) , serum leptin was in all measured by radioimmunoassay. Results: (1) Serum leptin levels of 58 patients with OSAS were higher not only in male ( 6.1±1.7 )g / L , but also in female (19.5 ±9.9) g/L than in simple obese controls [ male (4.5±1.1)g/L, female (10.5±2. 4) g/L] , (P<0.01, P<0.05). (2) Serum leptin levels were significantly correlated with BMI in both OSAS patients (r=0.637,P< 0. 01) and simple obese controls (r=0.585, P<0.01) , but in only OSAS patients were significantly correlated with apnea and hypopnea index (AHI) (r= 0.470, P < 0. 01) and with neck circumference ( r = 0. 641, P < 0. 01). Conclusion: Serum leptin levels are higher in OSAS patients than in simple obese controls, except for obesity and thicken neck , OSAS may also influence leptin system, results in increasing of serum leptin level.