A Clinic Study Of Pulmonary Infectious Complication After Allogeneic Bone Marrow Transplantation

ObjectiveTo explore the risk factors for, the incidence, pathogenic microorganism, clinical features, prophylaxis and treatment of pulmonary infectious complications in allogeneic bone marrow transplantation (allo-BMT) patients. MethodsThe clinical data of 29 cases with the pulmonary infection after allo-BMT were analyzed. ResultsThe risk factors for pulmonary infections after allo-BMT are not related to sex, age, transplant type ,underlying disease, veno-occlusive-disease and graft failure of the recipients. Graft-versus-host-disease andhemorrhagic cystitis significantly increase the morbidity of pulmonary infectious complication after allo-BMT.Infections were mainly caused by gran-negative bacteria and cytomegalovirus. Of the 29 patients, 17 were rescued, 12 failed. ConclusionThe pulmonary infection after allo-BMT was complex feature, high mortality and poor prognosis. Intensive care and active measures should be given to the pulmonary infection after Allo-BMT.The key points of successful treatment involve early pathogen diagnosis and using the in time applicant of abundant, extended-spectrum and combined antibiotics.