The Clinical Study On The Medicine Which To Improve Hypertension Patient's IR

The clinical study on the medicine which to improve hypertension patient's IRFollowing conclusions are made after reviewing a great deal of documents: IR (insulin resistance) is the mechanism of various metabolism diseases. To explore the reasons that IR can lead to hypertension and depressed affect IR. It is thought that IR is an independent factor of hypertension. The evaluation of depresses TK& tm\y depends on the decrease of blood pressure but the improvement of IR.There are various IR among hypertension's different syndromes. IR can be treated as an objective index while different syndromes. The Chinese herbal can in some degree improve the IR which have to be explore further.Objective: to evaluate the effect of Bu Shen Yi Xin Pian to the IR of hypertension patients, and also to inqure the mechanism.Methods: Before clinical study, select 30 healthy persons randomly, observe the fasting insulin level while dialouge hypertension. It is concluded that when fasting insulin level >17.02uIU/ml, can be dialogued hyperinsulin and ER. In clinical study, chose 50 hypertension patients combined with IR, divided into two groups randomly, control group which was treated with Nitrendipine lOmg Tid, Betaloc 25mg Bid, HCT 12.5mg Qd, and treated group which was treated with Bu Shen Yi Xin Pian additional. Before and after treated, survey OGTT or fasting blood, IRT or fasting insulin, blood-lipid, blood uric acid. Divided the 50 samples into such 5 groups as flaming-up of liver-fire, sputum and dampness, hyperactivity of yang due to deficiency of yin, deficiency of both yin and yang, blood stasis blocking collateral, at the same time, divided them into 3 groups according to the blood pressure, so it is with the treated group of 26 samples.Result: Contrasted before and after treatment, the treated group was improved greatly(p<0.05), In addition, different blood pressure has different IR, the higher rank of pressure, the higher IR level.Conclusion: Bu Shen Yi Xin Pian can improve the insulin sensitization index, alleviate insulin resistance.