Clinical And Experimental Study Of Jiangdan Decodion In Treating Chronic Renal Failure

Objective:To study and explore the clinical curative effect and active mechanism of Jiangdan Decoction(JDD) in treating chronic renal failure(CRF).Methods:1.60 cases of CRF patients were randomly divided into 2 groups.The treatment group(30 cases)\vere given JDD, and the control group(30 cases) were treated Niaoduqing pellets,2.Combine the case-control study of animal experiment.ResuIt:1. JDD can significantly improve the digestive system symptoms and physical strength of CRF patients. It can also reduce the urine protein.plasma lipids,BUN and Scr notably.The total effective rate of treatment group is 86.67%,better than that of control group(P<0.05).2.The experiment revealed JDD can restrain the crescendo-developed mechanism of CRF,which is achieved by decreasing blood ET-1,plasma lipids,urine protein etc.lt also can lighten glomerular sclerosis,inhabit uriniferous tubule-interstitial fibrosis.Al! these proved that JDD possess the quality of protecting renal function.Condusions:JDD can impede the crescendo-developed mechanism of CRF from various target points,protect renal function,improve the patients' life qualities,thereby delay the time beforeentering dialysis therapy.