A Case-Control Study On The Risk Factor Of Perinatals'in Seven Cities Of Guangxi Province

Objective: To investigate the incidence and the possible risk factors of congenital malformations in cities of Guangxi and provide basis for preventing congenital malformations and promoting birth quality. Methods: In 2000, 41539 perinatals were born in 62 hospitals of Nanning, Liuzhou, Guilin, Yulin, Wuzhou, Qinzhou and Beihai city, in which 513 cases of congenital malformations were diagnosed. A case-control study with 281 cases was carried out. Analysis of simple factor and multiple factors unconditional logistic regression was taken. Results: In all seven cities the total incidence of congenital malformations was 12.35%o, 13.32%o in male and 10.48%o in female with the sex ratio of 1.3 to 1.0 . The incidence of congenital malformations was higher in Wuzhou city and Yulin city, and lower in Beihai city. The incidence was 12.20%o in all city residents, and 11.55%o in villagers. But no significance was found between them. No significance was found either among the incidence of offspring from different maternal age group. In all types of congenital malformations the number of Bart's syndrome was the most. The analysis of simple factor and multiple factors showed that main risk factors of congenital malformations included following: low birth-weight(OR=0.999), multiple pregnancy(OR=2.6), pregnancy complications (OR=3.2),exposure to chemical substances before or during pregnancy(OR=3.0), taking sedatives(OR=10.2), hormone drug(OR=9.4) and Chinese herb medicine(OR=2.5) during the early stage of pregnancy,low content of hemoglobin(OR=0.985), fathers' exposure to noise(OR=5.7) or suffering from chronic diseases(OR=2.8). The risk of congenital malformations of offspring whose mothers' blood type was AB, A, B was respectively three times, two times, one time more than that of offspring whose mothers' blood type was type O. If mothers' emotion was nervous and melancholy, their offspring's risk was respectively two times, one time more than that of offspring whose mothers' emotion was pleasant. If mothers' occupation was workers and peasants , their offspring's risk was respectively three times, two times more than that of offspring whose mothers' occupation was staff,. No significance was found between staff and individual job. Conclusions: Enhancing pregnancy health care in high-risk group who having or exposing to above risk factors. Propagating extensively the knowledge of eugenics. Adjusting food composition. Avoiding taking some traditional Chinese medicine and western medicine that are harmful to pregnancy. Avoiding of exposure to some chemical substances. Keeping pleasant feeling. Risk factors that we have discovered deserve further research and will provide guidance reference for eugenics.