| Background Essential hypertension (EH) is one of cardiovascular diseases, which is threatening the health of human being badly. The incidence of EH in China is about 13.6%, that is, more than 100 million Chinese people suffer from EH, and the incidence of EH in China increase annually. The key therapy of EH is to protect the target organ avoiding damage caused by EH. At present, the study on damage of target organs on heart brain kidney and peripheral blood vessels due to EH is thorough, but we lack of the identical understanding about the changes of pulmonary ventilation function and diffusing function in patients with EH . Some studies at home and abroad showed a significantly decrease on pulmonary function in EH, and the pulmonary function will change with the level of EH. Up to now, there is no other study on pulmonary diffusing function in EH.Objectives The aim of the study is to investigate the changes of pulmonary ventilation function and diffusing function in essential hypertension patients and to explore if the pulmonary function will change with the aggravation of the grade level and risk degree of EH.Methods The characteristics of pulmonary function (FVC\ FEV1 -, MMEF<. MW\ DLcoSB ) in 67cases of untreated essential hypertension patients(48men and 19 women; 34~75years; mean age 60.13±9.52years) and 63 nomiotensives (41 men and 22 women; 42~74years;mean age 58.95 ± 7.08years) were examined with a blind and prospective study.Results (1) The results showed a significantly decrease in parameters on pulmonary function in patients with hypertension than that in normotensives, FVC 2.40±0.50 Vs 3.34±0.88, FEV1 2.01 ±0.40 Vs 2.72±0.77, MMEF 2.02 + 0.92 Vs 3.12 + 0.70, MW 69.35±19.96 Vs 93.67± 18.6, DLCOSB 5.65 ±1.71 Vs 7.34±1.50 (PcO.OOl). (2) pulmonary functions were lower in 2 and 3grade EH patients than that in 1 grade EH patients, FVC 2.20±0.41 Vs 2.66 + 0.49 (P<0.001), FEV1 1.82±0.40 Vs 2.25±0.24 (P<0.001), MMEF 1.83 + 0.98 Vs 2.26 + 0.79 (P >0.05), MW 65.82 + 22.75 Vs 73.98±14.7(P >0.05), DLcoSB 5.55 + 1.83 Vs 5.78±1.55(P>0.05). (3) Pulmonary functions were lower in moderate risk group compared with the mild risk group, but only FEV1 (2.15 + 0.29 Vs 2.32 +0.2l)have the significant difference (P<0.05). (4) Pulmonary functions were lower in high risk and very high risk group compared with the mild risk group, FVC 1.97 + 0.19 Vs 2.76 ±0.54 (P<0.001),FEV1 1.61 ±0.29 Vs 2.32±0.21(P<0.001), MMEF 1.69±0.87 Vs 2.33 ±0.68 (P<0.02), MW 64.25 ±21.60 Vs 75.03 ± 14.26 (P>0.05), DLCOSB5.34 +1.52 Vs 5.95 ± 1.74 (P>0.05). (5) Pulmonary functions were lower in high risk and very high risk group compared with the moderate riskgroup, FVC 1.97+0.19 Vs 2.54±0.40(P<0.001), FEV1 1.61 ±0.29 Vs 2.15 ±0.29(P<0.001), MMEF 1.69±0.87 Vs 2.10± 1.04 (PXX05), MW 64.25± 21.60 Vs 70.12±21.14 (PXJ.05), DLcoSB 5.34± 1.52 Vs 5.73± 1.85 (P>0.05).(6) Pulmonary functions in 1 grade were lower than that in normotensives, FVC 2.66±0.49 Vs 3.34±0.88 (P<0.001), FEV1 2.25 + 0.24 Vs 2.72±0.77 (P<0.005), MMEF 2.26 + 0.79 Vs 3.12±0.70 (P<0.001), MW 73.98± 14.70 Vs 93.67± 18.6 (P<0.001), DLCOSB 5.78± 1.55 Vs 7.34±1.50 (P<0.001).(7) Pulmonary functions in mild risk group were lower than that in normotensives, FVC 2.76±0.54 Vs 3.34±0.88 (P<0.001), FEV1 2.32±0.21 Vs 2.72±0.77 (P<0.05), MMEF 2.33 + 0.68 Vs 3.12±0.70 (P<0.001), MW 75.03 ± 14.26 Vs 93.67± 18.6 (P<0.001), DLCOSB 5.95±1.74 Vs 7.34 + 1.50 (P<0.001).Conclusions (1) The values of parameters on pulmonary ventilation function (FVC, FEVi, MMEF, MW) were lower in patients with EH than that in normotensives significantly, the results showed pulmonary ventilation function in patients with EH were damaged. (2) With the aggravation of the grade level and risk degree of EH, both the values of FVC and FEVi and the values of MMEF and MW decreased, but the latter have no significant difference (P>0.05). The data suggested that pulmonary ventilation function might decrease with the aggravation...
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