Influence Of Hemorheology And BBB In Early Stage Of Mssile Craniocerebral Injuries In Cats Under High Temperature And High Humidity Circumstances

Influence of hemorheology and BBB in early stage of mssile craniocerebral injuries in cats under high temperature andhigh humidity circumstancesPostgaduate:Ma De XuanTutor:Xu Ru Xiang professorAbstract:Missile craniocerebral injuries(MCI), which lead to lots of death and mutiltion, are an important question for study in military medicine, MCI always occur in special circumstances such as areas of high temperature and high humidity circumstances (HTHFIC) which hadn't been studied before. Our experiment studied pathophysiological changes in early stage and probable mechanisms of MCI at microcirculation level in order to search for effective means of prevention and cure.The experiment selected 86 adult hybrid cats to establish the model of MCI and to simulate high temperature and high humidity circumstances in order to study changes of hemorheology and BBB in early stage. The research is composed of three parts of experiment:Partl The experiment explored to establish the model of MCI under HTHHC and observe the changes of the essential Vital signs by the Ploygraph System RM6000. The conclusions are as below:(1)We successfully established the model of MCI underHTHHC.(2)HTHIHC can greatly affect the death rate after Missile craniocerebral injuries.Partll purpose of the experiment was to study the changing of early Flemorrheolgy in missile craniocerebral injuries and observe microvascular through the brain microvascular corrocion casts by electronic microscope.(1)HTHHC insulted in rising of all blood rheological parameters significantly after MCI. The results are as below:-4-(2)The morphologic damage of brain mircocirculation was severely.(3)Treated with Sodium Aescinate improved the hemorheology and ameliorated the impaired brain microcirculation.Part Iii. The aim of the experiment was to study the changes of blood-brain barrier(BBB) in MCI under HTHIIC. Extent of BBB damage was evaluated by measuring the content of Evans blue. The conclusions are as below(1) The damage of BBB in MCI under HTHIZJC is very serious. It is not only confined to impaired area of brain, but also spread to contraleteral cortex~ white matter and hippocampus.(2) Sodium Aescinate has protective effects on BBB.Results above indicate that HTH[IC play a cirtical role in the impaired brain microcirculation and brain tissue in MCI. HTHI]IC is the secondary brain injuries to increase death rates and Mutilation in MCI. Our results provide a new way to the treatment to lessen and ameliorate the impaired brain microcirculation in the clinical emergency treatment.