Clinical Study On SPECT Cerebral Perfusion Image In Patients With Vertebrobasilar Insufficiency

Purpose: Investigating the clinical application of SPECT brain perfusion image in VBI and through a comparison with other VBI research methods in order to find out an objective and ideal clinical method for VBI research. Method: We used TCD,CDF1 and SPECT examination in everyone of 40 patients who had been clinically diagnosed VBI in those patients with normal result of SPECT examination ,each one took orally 2g acetazolamide 48h afler, then took SPECT examination again 2h later. 13 of the 40 patients received MRA examination, one of the 13 patients received PET examination. Result: The data of the 40 patients were as follows: The positive percentage through TCD was 62.5%; The positive percentage through CDFI was 55%. The positive percentage with ordinary SPECT was 60% and not much difference was showed,when compared with the TCD and CDFI methods. But a marked difference was revealed after acetazolamide SPECT examination,as compared with TCD and CDFI methods. The positive percentage after acetazolamide SPECT examination was up to 85%. SPECT showed the ischemic area located in the occipital and temproal lobes supplied by VBA system.The MRA showed two of the 13 patients suffered from the narrowing of vertebral artery. One patient with normal MRA and ordinary SPECT exainination,was found to suffer from occipital and temporal lobes ischemia after acetazolamide SPECT examination and PET scan. Conclusion:Our investigation shows that TCD and CDFI can be used as a relatively simple and rough method for VBI research.The MRA in detecting VBI is not so valuable. Acetazolamide SPECT examination is much more useful in the clinical application of VBI, and it is worth to be introduced.