| Background and Objective: The incidence of central nervous system infection islower than that of other organs or systems because there is the blood-brain barrier and blood cerebrospinal fluid barrier in central nervous system. The clinical situation is critical if the central nervous system is infected. And the fatality and themutilation rate are high. In order to investigate the clinical characteristics, the positive rate and specificity of examination, and define the clinical diagnostic criteria of early stage of various kinds of central nervous system infectious diseases, the clinical data of 247 cases in 22 years were studied retrospectively. Materials and Methods: Records of 247(male 191, female 56) hospitalized patients of intracranial infectious diseases from May, 1979 to June, 2000 were reviewed. There were 72 cases of viral meningitis, 67 cases of tuberculous meningitis, 13 cases of purulent meningitis, 6 cases of fungal meningitis, 58 cases of viral encephalitis, 11 cases of herpes simplex virus encephalitis and 20 cases of brain abscess. The clinical materials included the general material, history, pattern of onset clinical manifestations, CSF results, image change and pathological findings. The data were analyzed with variance test.-6-respir8tory tract infection; for puru1ent meningitis and brain abscess,15$had otitis media history and 12% had a recent oper8tion history;52% of tubercu1ous meningitis had 8 formr history of extracrania1 TB;3 cases of herpes siIIlP1ex virus encePha1itis had periora1 herpes history;3 cases of fullga1 meningitis had TB history, areng which 2 cases hada 1ong term history of steroids administr8tion.The onset of Perulent meningitis, vira1 areningitis and vira1enc6Phalitis were chiefly acute, and the onset of fUng1 meningitis,brain abscess and tubercu1ous meningitis were PYominently chronic.Headache wns most severe in Pnyu1ent and fung81 meningitis. EPi1epsy,psychiatric spotoms and disturbance of consciousness 'ere mostconnnon1y seen in herpes simp1ex virus encePh81itis. And vision decreasewas most camnly seen in funga1 meningitis. P8Pil1edema wis mostconnnon1y seen and severe in chronic meningitis groUP. Limb para1ysiswns sost counnnly seen in brain absceIss. And sensory disturbance wasmost connnnly san in Purulen Ineningitis. bo eq signS were more inmeW po and it was pe in eVny case of PUrUlen meninghs. For the 2lcases of TB meW ed withe 28 day ds OnSet, 43% was - 52% wastw and 5% bad no tw AmOng the ll cases of hmpes wi thewts, 55% was W 27o/o was tw and l8% bad no effe4 the totalfor the was 82%. AmOng the 247 cases, l34(54% cases were - 73(30%)cases were ~ 23(9%) case were deterioW l7(7% cases were dirt thetotal de the was 84%.2. CSF rech@ W W: WBC are inCreaSed in 77% cases ch the for week, with77% lyInpocpe, in the SeCOnd week, wh 86% lyInpocpe. The WBc cOUn and~ cota bod ~ m ed or -- ana reas antoed m wi.@ twen --: lh the ha week, CSF was clOUdy in 42% cases; WBCwas PrOInined bo in 92% cases, wh more bo 90% -- in 42%cases. Protein coIIten was over l000Ingh in 83% cases. Gforose and bo weredeCreaSed in 75% and 88% cases W 25% case had a POaitiVe smearresuha, wh 2 cases POaitiVe culta results.@ bo mewt: WBc was increaSe in 92% cases in the ha week,and also the dera of glUCOe and chloride wer COIInnonl sere The changn OfWBc, Protein cond and glUCOSe was stead and the tw of bo wnSOIneWbat be. Ade fat was pothe in 2% cases, PCRTh DNA wasPOW M in 33% cases, and l9Ok cases had a POaitiv cuIthe resulL@ FUgal eds: In the early Stag, the CSF pessure was op ID moforinCreaSe, WBC was Promintw inCreaSed and the inrme of Protein cond wasslight. tw the ed Stag4 CSF Pressure was motw eIeW WBC wasinrmed in 69% cases, amODg nd it was op bo in 54% CaSeS andthe Protein coDten was still sw inCreaSed. Indian ink was POsthe in 55% caseSand 44% cases bad a POfor culin ed@ M encwts: The CSF PreSsure was slightiy N WBC also had asligh increase wh lyInw...
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