| Cows endometriosis is harm of milk cow industry is one of the four disease treatment, if not treated or improper measures, often affect the production of milk cow industry, fecundity and caused serious economic damage. Looking for more effective safer more practical treatment method is very necessary. This experiment is developed in obstetrics teaching medicine treatment of cow endometriosis square is conducted on the basis of the corresponding processing enrichment, considering the biological agents for endometriosis cow in the treatment of traditional Chinese medicine and advantages, biological agents(lysozyme) combinations. Lysozyme and traditional decoction can not be mixed with use, Chinese herbal medicine can cause the bacteriolysis enzyme deactivation, so a new kind of suppositories is two drugs can be used cooperatively.Suppositories is rapidly, the effect is form has good curative effect of stress, low cost, small, so in medicine and lysozyme choose when a new combination of suppository forms, lysozyme effervescent bolt form, make not only so can rapidly release lysozyme and can increase the contact area with uterine drugs. Will make Chinese decoction has sustained in the form of the hollow bolt, so can make medicine at the time of release and lysozyme separately, and the role of time to avoid the bacteriolysis enzyme and traditional decoction mixes the efficacy of decline. The experiment of lysozyme effervescent bolt matrix and herbal controlled-release hollow bolt matrix, and the selection of lysozyme effervescent bolt physical properties: shape, colour and lustre, weight difference, pH value, effervescent duration and foam is tested by orthogonal experiment and test results, and the best formula for production process was studied, the TCM controlled-release hollow bolt is selected by orthogonal experiment to release to the best formula about 24h matrix, and analyses the characters of physical examination: shape, colour and lustre, weight difference, pH value, melting point. In the clinical trials on the head with a selection of 25 endometriosis cows, divided into three groups, a group of ten head for lysozyme effervescent bolt and does not have the function of slow-release 24 hours YaoShuan interval partial to medicine. Two groups of 10 head for lysozyme effervescent bolt and medicine and chemical controlled-release hollow bolt. Three groups of five heads for control processing not.Results show that lysozyme effervescent bolt and herbal controlled-release hollow bolt physical traits which conform to the national regulation, regardless of the 2005 version of pharmacopoeia foam and duration of effervescent are achieved ideal effect. In the clinical trials found that while dosing and partial medicine has similarly results, therapeutic effect of endometriosis cows pregnancy rate reaches 70%. Precise production process can be used in small batch production. |
