Effects Of Bactrian Camel Fermented Milk On The Anti-stress And Antioxidant Capacity Of Mice

To investigate the effects of bactrian camel fermented milk on the anti-stress and antioxidant capacity of mice, the some related indicators of anti-stress and antioxidant were systematically evaluated on kunming mice administered with different doses of camel milk in this study. In anti-stress experiment: the experimental animals were randomly allocated into 3 group of groupâ… ,â…¡andâ…¢. Groupâ… was the control, received 0.3 mL / 10g dose of normal saline; Groupâ…¡a ndâ…¢were experimental group administered by per os with 0.15 mL/10g and 0.3 mL/10g of bactrian camel fermented milk respectively for 7 successive days. Then the effects of fermented camel milk on the time for loading swimming, hypoxia survival, heat resisting survival and cold resisting survival of mice were detected. As well as, the effects of fermented camel milk on the daily weight gain, feed conversion rate, thymus and spleen index, the content of serum glucose, albumin and total protein, the activity of alkaline phosphates (AKP), creatine kinase (CK) and lactate dehydrogenises (LDH) were examined in chronic heat stressed mice, respectively. In Antioxidation experiment: the dose and administration route of fermented camel milk were same as anti-stress experiment. After 30min of last administration, blood samples were collected and the activity of total superoxide dismutase(T-SOD), catalase (CAT), glutathione peroxidase (GST-PX), total antioxidation capacity (T-AOC) and the content of malondialdehyde (MDA) in liver, muscle and brain tissue were detected respectively.The result showed that Bactrian camel fermented milk in high-dose group significantly extended the time of loading swimming, hypoxia survival, heat resisting survival of mice, and significantly increased the content of serum total protein and glucose and significantly decreased the activity of AKP and CK. Compared with the control group, the high dose of the Bactrian camel fermented milk significantly decreased the activities of GSH-PX, CAT and T-AOC and the content of MDA in serum, liver, muscle and brain tissue, respectively; significantly increased the activities of T-SOD, GSH-PX, CAT and T-AOC in serum, muscle and brain tissue, respectively. However, there were no significant regularity for the activities of T-SOD, CAT and T-AOC in liver at the high dose of the Bactrian camel fermented milk group. Therefore, Bactrian camel fermented milk has a certain effects on anti-stress and antioxidant capacity of mice.