Safety Experiment Of Bevenil Liposome And Field Protection Experiment On Theileriosis In Sheep

In order to check up the safety of Bevenil Liposome,a new medicine,the acute toxicity experiment was carried out with little white mouse as experimental animal and self-animal,and compared with Bevenil Injection.As a result,there was a obvious distinction between the Liposome group and the original medicine group.The LD₅₀(74.14mg/kg)of the Liposome group was higher than the original medicine group(74.14mg/kg),the multiple was 2.4.It was indicated that Bevenil Liposome could reduce toxicity and side effect greatly,and improve it's security.There hasn't ill effects that use a high dose more than the recommended dose inject self-animal.It's signify the Bevenil Liposome has a high safety for self-animal,and hasn't a obvious toxicity and side effects.There had a prevention effect observe experiment was carried out in Minxian and Yongjing county for Theileriosis.454 Sheep were divided into three groups—Bevenil Liposome prevention group,Bevenil Liposome add to Miepilin prevention group and comparison group.To be the result that inject Bevenil Liposome by single had a good prevent effect to Sheep's Theileriosis.The period of prevention was 37 days,incidence of a disease was 7.39 after three mouths,less than comparison group was 41.57 percent. There had a better effect for Bevenil Liposome add to Miepilin prevention.The period of prevention was 61 days,incidence of a disease was 2.19 after three mouths,and a obvious distinction was found with comparison group.In Kangjiaji township of Lintao county,Zhucha township of Tianzhu county, Yongjing county,Zhangchuan county and Minxian county,and so on,in which was the epidemic zone of Sheep's Theileriosis.A treatment effect comparison experiment between Bevenil Liposome and general medicine was carried out and involve 1620 sheep. The experiment including Bevenil Liposome treatment group,Bevenil treatment group, the medicine named Jiaochongjin treatment group,Imidocarb treatment group and comparison group.The sheep number was 314,410,360,378 and 158 accordingly.It was indicated that was the best treatment effect for Bevenil Liposome,cure-rate reached 96.82 percent,and there had a short period of treatment,quick effect,almost haven't poisoning and side effect.Bevenil Liposome was the best medicine treatment Sheep's Theileriosis.