Pharmacokinetics And Residue Depletion Of Narasin In Carp

Narasin is one of polyether ionophores, it is used as a growth promoter and chemotherapeutic agent for swine and chickens now. Aquiculture is one of the swift foodstuff production trade in the world and it enormously contribute to national commissariat safety and loftily agriculture structure, it can help us to breake away poverty. Aquiculture is developing by continuable mode; it creates food and takes up an occupation, ameliorates income and living of country and city, thereby reduces starvation and penury. Since narasin is good promoter and the aquiculture is short of effective promter, this study is aimed to expand the narasin marker animal and adaptive symptom, it is useful to aquatic food additive transition and offer the reference of safe use and residue determination. This study is based on the experimentation of promoter, in this study several methods had been developed as following: HPLC determination of narasin in carp plasma, tissues and waters. Average recoveries, detection limit and relative standard deviation were studied. Pharmacokinetics and residue depletion in tissues of narsin were studied in carp. This work is to reveal the absorption and excretion of narsin in carp, further to determine the marker residue and target tissue, and to estimate a withdrawal time of narasin for carp after in-feed administration, and meanwhile to establish the method which can be used to control its residue in tissues.Pharmacokinetics of narasin in carp plasma was studied by IV and oral administration. Carps were administrated narasin intravenously with a single dosage of 0.2mg/kg b.w.. The concentration verus time was fitted with open two compartments. The T1/2α and T1/2β were 0.1h and 0.53h, respectively. The V_d was 0.08L/kg, and the AUC was 1.66(μg/mL)·h, which indicated that narasin could be distributed rapidly in carp. When carp was administrated narasin orally with a single dosage of 1mg/kg b.w., the concentration verus time was fitted with open one compartment. The T1/2α and T1/2e were 0.19 h and 0.58h, respectively. The AUC was 6.72(μg/mL)·h, Cmax was 4.15μg/mL and...