Real - Time Clinical Observation And Central Response Of Orthodontic Push - Bridge In The Treatment Of Essential Hypertension

Objective:To compare the clinical efficacy achieved by tuiqiaogong in opposit e directions in the treatment of primary hypertension and the effect it has in t he activation of CNS regions, to assess the treatment mechanism of tuina.Method:30 patients who met the diagnostic standard for primary hypertension and inclusion criteria were separated into two treatment groups, with one grou p receiving tuiqiaogong technique in the traditional direction, and the other gro up receiving tuiqiaogong technique in the opposite direction.15 healthy testers served as the control group.Blood pressure were measured before and after trea tments and CNS responding regions were observed before and after treatments using fMRI.Result:1.) Patients in the treatment group receiving downward-pressing Qiaogo ng had a statistically significant reduction in systolic blood pressure (P=0.0126 (P<0.05)) and diastolic blood pressure (P=0.1065(P>0.05)) after treatment compared to the control group. Patients in the treatment group receiving upwar d-pressing Qiaogong did not demonstrate statistical significance in the systolic blood pressure reduction (P=0.8146 (P>0.05)) compared to the control group, however, the diastolic blood pressure reduction did exhibit statistical significanc e. (P=0.4111 (P>0.05)) 2.) Compared to the control group, hypertensive patie nts had a lower resting state ALFF signal in the bilateral temporal lobe, left ci ngulate gyrus, supramarginal gyrus, occipital lobe and right thalamus. Hypertens ive patients also demonstrated lower functional connectivity between the thalam us and cerebellum, right hippocampus, parahippus, insula, temporal lobe, frontal lobe, anterior cingulate gyrus and medial cingulate gyrus and higher functional connectivity between the thalamus and the medial temporal region, medial occ ipital region and supramarginal gyrus in the resting state CNS network with th e thalamus as the focus point.3.) Patients receiving downward-pressing Qiaogo ng demonstrated higher functional connectivity between the thalamus and the o ccipital lobe and right medial cingulate gyrus and lower functional connectivity between the thalamus and temporal lobe, parahippus, frontal lobe and posterio r cingulate gyrus compared to patients receiving upward-pressing Qiaogong.Conclusion:1.) downward-pressing Qiaogong has a significant lowering effect on the systolic blood pressure and moderate lowering effect on the diastolic bl ood pressure in patients with primary hypertension. upward-pressing Qiaogong does not exhibit such lowering effects.2.) The mechanism of tuiqiaogong tech nique in the lowering of blood pressure is related to its effect in increasing th e functional connectivity between the thalamus and the occipital lobe and right medial cingulate gyrus and decreasing the functional connectivity between the thalamus and the temporal lobe, parahippus, frontal lobe and posterior cingulate gyrus.