| Objective: To investigate the effect of Ozagrel sodium on the cardiac function in patients with ischemic cardiomyopathy and the exercise tolerance in patients with chronic heart failure.Methods: All cases of patients with chronic congestive heart failure caused by coronary heart disease who were admitted into Qingdao Hospital from Nov,2012 to Oct,2013. The patients were randomly divided into control and treatment groups.The control group were treated with aspirin statins angiotensin converting enzyme inhibitors(ACEI), beta blockers, diuretics, Aldosterone receptor antagonist and nitrates and other conventional treatment. The treatment group was treated with routine method combined with Ozagrel sodium injection(Ozagrel sodium injection, 80 mg, qd). Six minutes walk test was measured by the method proposed by Bittner,and the serum levels of BNP were detected by multifunctional immunoassay. The INR values, liver function and renal function levels were observed at same time.Results: Ten days after treatment with Ozagrel sodium injection, the cardiac ejection fraction and exercise tolerance of the trimetazidine group improved than that of control group, while BNP average level lowered, which were all significant(P < 0.05). INR values, liver function and renal function were no statistical significance(P>0.05).Conclusion: Ozagrel sodium could improve the heart function and exercise tolerance in patients with ischemic cardiomyopathy, and the treatment effect is exact and safe. |
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