Retrospective Analysis Of Risk Factors Of Type 2 Diabetes Mellitus Complicated With Cerebral Infarction

Purpose:Through the analysis and comparison of the characteristics between cerebral infarction and non-cerebral infarction in type 2 diabetic mellitus(T2DM) patients from the Endocrinology Department in Liaoning University of Traditional Chinese Medicine Affiliated Hospital to explore Traditional Chinese Medicine(TCM) syndrome distribution and risk factors of cerebral infarction in T2 DM, and improve the understanding of that to provide evidence for early prevention of the disease.Material and method:Collect screened 521 cases whit T2 DM in Endocrinology Department in Liaoning University of Traditional Chinese Medicine Affiliated Hospital from September 2013 to March 2014. 82 cases in which had cerebral infarction group and non-cerebral infarction group 439 cases. According to 《Guidelines of clinical research of Traditional Chinese Medicine(trial)》 in 2002 of syndrome differentiation,analyzed and recorded gender, age, syndrome differentiation, Western medicine diagnosis, duration of diabetes, a history of coronary heart disease, hypertension, cerebral infarction history, smoking history, drinking history, BMI, blood lipid, Hb A1 c, uric acid, C-reactive protein. Collected all the data and eliminate the syndrome differentiation which were less, then the selected data would be entered into the computer by using SPSSl9.0 software for statistical analysis. When measurement data with normal distribution were compared using the t test, if did not meet the normal distribution used nonparametric test, comparing count data were using the chi-square test, when P <0. 05 was considered statistically significant. Researching risk factors chose Logistic regression analysis.Results:1. The group of cerebral infarction in T2 DM :71 cases accounting for 86.59% were belong to both Qi and Yin deficiency syndrome, 7 cases accounting for 8.54% were belong to both Yin and Yang deficiency syndrome, 3 cases accounting for 3.66% were belong to humid and heat trapped the spleen syndrome,1 cases accounting for 1.22% were belong to hyperactivity of heat due to Yin deficiency syndrome. The group of non-cerebral infarction in T2 DM :both Qi and Yin deficiency syndrome in 380 cases, accounting for 86.56%, both Yin and Yang deficiency syndrome in 40 cases, accounting for 9.11%, humid and heat trapped the spleen syndrome in 16 cases, accounting for 3.64%, hyperactivity of heat due to Yin deficiency syndrome in 3 cases, accounting for 0.68%.2. Age, duration of diabetes, smoking history, history of coronary heart disease, hypertension, Apo AI, LPa has statistical significance(P<0.05) by comparing the two groups.3. Logistic regression analysis showed that: the older, the more long history of diabetes, smoking, hypertension, coronary heart disease history, low Apo AI, high LPa were risk factors for cerebral infarction in T2 DM of both Qi and Yin deficiency syndrome.Conclusion:1. Both Qi and Yin deficiency is the most common syndrome in T2 DM and cerebral infarction in T2 DM.2. Age, duration of diabetes, smoking history, history of coronary heart disease, hypertension, Apo AI, LPa are closely related to cerebral infarction in T2 DM of both Qi and Yin deficiency syndrome.3. The older, the more long history of diabetes, smoking, hypertension, coronary heart disease history, low Apo AI, high LPa are the main risk factors for cerebral infarction in T2 DM of both Qi and Yin deficiency syndrome.