Clinical Study On Treatment Of Diabetic Nephropathy By Bushen Huoxue

Purpose：To observe the clinical efficacy of tonifying kidney, promoting bloodcirculation and removing blood stasis method on diabetic nephropathy(Ⅲ～Ⅳ).Material and method：A total of44patients with diabetic nephropathy(Ⅲ～Ⅳ),those belonged to kidney deficiency and blood stasis type in traditionalchinese medicine,were enrolled through the affiliated hospital of LiaoningUniversity of Traditional Chinese Medicine. All patients were randomly dividedinto the treatment group and the control group,each group were22patients.4patients were lost in the treatment group and2patients were lost during followup. Both of two groups received the basic treatment including diabetes education,control blood glucose and blood pressure, regulate blood fat and so on. Meanwhile,patients in the treatment group received a chinese medicine treatment.After8weeks,main clinical symptoms and signs and lab indexes of patients belonged tothese two different group were observed and compared with each other.Results：1.The treatment group was significant better than the control group intraditional chinese medicine symptom integral(P＜0.05).2.The total effective rate of traditional chinese medicine syndrome curativeeffect of the treatment group was higher than the control group (88.88%vs55.00%;P＜0.05).3.Blood glucose and glycosylated hemoglobin have been decreased significantlyin both of two groups after therapy(P＜0.05), but no significant difference wasobserved between the treatment group and the control group(P＞0.05).4.Total cholesterol, triglyceride and low density lipoprotein have beendecreased significantly in both of two groups after therapy, the efficacy of the treatment group was better than the control group (P＜0.05).5.The rate of urinary microalbumin/urine creatinine was significantly decreasedin treatment group after therapy (P＜0.01), the efficacy of the treatment groupwas better than the control group (P＜0.05).6.There was no significant difference in the hepatic and renal function betweenthe treatment group and the control group after therapy (P＞0.05), and therewas no adverse effect on all patients.Conclusion：This research showed the tonifying kidney, promoting blood circulation chinesemedicine had improved the clinical symptoms, decreased the urinary microalbuminand improved lipid metabolism in patients with diabetic nephropathy without theadverse effect.This research provided a new pathway to treat diabeticnephropathy.