| Background:Cancer is one of the major chronic diseases that threat the health of Chinese residents, with the development of industry and economy, environmental degradation and the population aging in recent years, various cancer incidence and mortality rate are on the rise in our country. Malignant tumor has become the first reason of the residents’ death in both urban and rural areas of our country. Currently, lung cancer has the highest incidence and the largest number of malignant tumor cases, the poor prognosis is mainly due to local recurrence or distant metastasis. Lung cancer patients with brain metastases are in the terminal of disease, the prognosis is poor and the naturally median survival is short. The treatment mainly aims at improving the symptoms and the quality of life while prolonging survival time to maximize, using reasonable, planned comprehensive of existing treatments for comprehensive treatment according to location of the tumor, histological type, extent of involvement, developing trends and physical condition of the patients. The effect of western medical treatment is undeniable, but the characteristics of high strength, high-dose, long periods often make patients miserable. The Chinese medical treatment plays an important role in toxicity attenuation and efficacy potentiation, adjuvant with western medicine, and as the main treatment for patients with advanced cancer. Huatan Xifeng Qingnao Fang is the summary of experience in the treatment of lung cancer with brain metastasis of the author’s teacher, which is modified by Er Chen Tang. The using in clinical can improve some of the symptoms of the patients and enhance their physical conditions.Objective:A retrospective analysis of the clinical efficacy of non-small cell lung cancer patients with brain metastasis while Huatan Xifeng Qingnao Fang involved in the comprehensive treatment based on radiotherapy. Research the influence to the symptoms, Karnofsky score, radiotherapy toxicity and brain metastasis progression free survival (PFS) and overall survival (OS) of the prescription.Methods:According to the established standard of diagnosis, inclusion and exclusion, collect 33 cases who had only taken the basic treatment based on whole brain irradiation (as the control group) and 35 cases who had taken the traditional Chinese medicine prescription at the same time (as the treatment group) from all the non-small cell lung cancer patients with brain metastasis who took the treatment of WBRT (40Gy/20f/4w) in Guang’ anmen Hospital during June 2011 to June 2013. Collect and analyze the data of objective effect, Karnofsky score, clinical symptoms, adverse reactions, and progression free survival, overall survival getting from the two groups of patients before and after the treatment.Results:Treatment of Huatan Xifeng Qingnao Fang combined WBRT compared with simply WBRT, the objective effect showed no statistical difference while the effective rate of the treatment group was 34.3% and the control group was 33.3%. The evaluation of Karnofsky score improvement:the effective rate of the treatment group was 45.7% and the control group was 21.2% (P<0.05), which means the physical condition of treatment group was better than the control group. Improvement of clinical symptoms of the two groups of patients:dizziness, headache and fatigue had significant difference by statistically analysis (P<0.05) while hemiplegia, convulsions, seizures, sensory impairments, mental retardation had no significant difference (P> 0.05). On the bone marrow suppression side, the white blood cells and platelets bone marrow suppression incidence had no significant difference between the two groups (P> 0.05), but the treatment group had a lower statistically significant hemoglobin bone marrow suppression incidence (P<0.05). Median PFS of the patients in treatment group was 3 months, PFS average distribution of the sample was 3.37±0.077 months; median PFS of the patients in control group was also 3 months, PFS average distribution of the sample was 3.12±0.992 months, there was no statistical difference between the two groups (P=0.256>0.05). Median OS of the patients in treatment group was 5 months, OS average distribution of the sample was 5.11±1.231 months; median OS of the patients in control group was also 5 months, OS average distribution of the sample was 4.70±1.212 months, there was no statistical difference between the two groups (P=0.176>0.05).Conclusion:To treat the non-small cell lung cancer patients with brain metastasis using Huatan Xifeng Qingnao Fang combined with WBRT can not only effectively improve the clinical symptoms such as dizziness, headache, fatigue, and enhance the physical condition of the patients, but also protect normal tissue cells to reduce the occurrence of radiation-induced toxicity such as bone marrow suppression, so as to improve the quality of patients’life.
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