Elemene Injection Combined With Radiotherapy For Non-small Cell Lung Cancer With Brain Metastasis In Patients With Clinical Research

As the incidence rate of lung cancer rising, in the male rate of tumor,which is the first,and in the female of tumor is the third.There is no small cell lung cancer,with its incidence of about 80%, brain metastasis is 20% of NSCLC, which is the 40% in autopsy. Some literatures report the incidence rate of brain metastasis is 25%—35% in the tumor,which comes from lung cancer is 50%, breast cancer is 20%,next to the gastrointestinal Cancer and malignant melanoma. The brain metastasis patients already belong to advanced stage,which can not cure,so we improve the cancer patients quality of life and extend their life span to accommodate the development patterns and requirement of the Modern Medicine.The treatment of modern medicine is high intensity,large dose and long period, which makes the patients painful beyond description.Many patients bear the double pain of spirit and body.At the same time,the assistance therapy of the traditional chinese medicine and the major therapy of the modern medicine all educe significant action.The traditional Chinese medicine have long history, plenty experiences,because it can remove our resistance to resist diseases. With the chinese medicinal pharmaceutics developing in the study of the modern de materia medica,which provides condition for the traditional Chinese medicine in the future. The Elemenum Emulsion is abstracted of blue turmeric rhizome who is a anticancer drug. Chinese medicinal think it is warm and bitter,which resists cancer. The clinic practice demonstrate that The Elemenum Emulsion can lessen adverse reaction and improve the quality of lives for cancer patients.This study adopted randomized control trials and prospective clinical research method,and combined the Elemenum Emulsion with radiotherapy to improve the clinic symptoms for patients and boost the quality of lives.Objective:To observe the clinical efficacy of the combination of the Elemenum Emulsion with radiotherapy for brain metastasis of NSCLC. We research the Elemenum Emulsion may improve some symptoms,boost KPS,improve the quality of lives and lessen adverse reaction,which is caused by radiotherapy.Methods:Research is guiding the use of modern evidence-based medicine, randomized controlled method, specific groups by random table, do prospective clinical study, in accordance with the diagnostic criteria, inclusion, exclusion, falling standards of our hospital and the Sino-Japanese Friendship Hospital were randomly assigned divided into treatment and control groups.The two groups both adopte modern therapy which is simple radiotherapy of the whole brain(40gy/20f).The treatment group which added the Elemenum Emulsion by intravenous drip infusion at the same time(400—600mg/day two weeks),and the control group does not any intervention.To observe the clinical efficacy of the two groups for metastatic tumor. the improvement of clinical symptoms,the change of KPS,the elevation of the quality of lives and adverse reaction. patients. There was no evident difference in the clinical efficacy of metastatic tumor between the Elemenum Emulsion combined radiotherapy and simple radiotherapy,9 cases were efficient(30%) in the treatment group and 6 cases were(20%) in the control group, the treatment group surpassed the control group.In the value of KPS aspect, the effective power of the treatment group is 43.33%,but the control group is 13.33%.There was significant difference between the both groups(P<0.05).The provement of clinical symptoms, the average improvement rate is 53.49%±10.98%in the treatment group,and the control group is 50.37%±12.45%.There were differences in short breath,cough,expectoration,lack of power. chest pain, dyspnea, dizziness. headache,but no significant differences in (P>0.05) Aphasia. hemiplegia. Mental aberration, seizure disorder, dysgnosia. the change of sight. sensation disorders, the change of character and behavior. The aspect of the quality of lives,the total of rating scales, the treatment group is 94.823±5.604 and the control group is 87.545±8.006,there were differences in Physiological Well-Being. Social/Family Well-Being. Emotional Well-Being. Functional Well-Being(P<0.05). The treatment group is better than the control group,whereas no evident difference was found in the Lung Complementation Supervention(P>0.05).The aspect of adverse reaction,there was difference(P<0.05) in white blood cell,and no difference in baldness, hemochrome. blood platelets(P>0.05).Conclusion:1.Compared the Elemenum Emulsion combined radiotherapy to simple radiotherapy, may boost the KPS of the patients.2.Compared the Elemenum Emulsion combined radiotherapy to simple radiotherapy,may improve some symptoms of the patients.3.Compared the Elemenum Emulsion combined radiotherapy to simple radiotherapy,may elevate the quality of lives of the patients.4.Compared the Elemenum Emulsion combined radiotherapy to simple radiotherapy,may decrease effectively adverse reaction of radiotherapy.