| Objective:Patients with chronic kidney disease (CKD) have an unacceptably high risk of death, primarily as a result of cardiovascular disease (CVD). The ’hypertriglyceridemic waist" phenotype has been proposed as a simple and strong predictor of CVD risk. Therefore, we investigated the relationship between the hypertriglyceridemic waist phenotype and carotid atherosclerosis in CKD patients.Methods:In a cross-sectional study, we enrolled785prevalent CKD patients [416males, aged44.6years (21.7-69.4), glomerular filtration rate52.5ml/min/1.73m2(5.3-119.4)]. We divided the patients into three groups:group1:waist circumference>90cm in men or>85cm in women and triglycerides≥2mmol/1(n=109); group3:waist circumference≤90cm in men or≤85cm in women and triglycerides<2mmol/1(n=379), and group2:the remaining patients (n=297). Routine biochemical parameters and carotid artery intima-media thickness (IMT) were measured.Results:The prevalence of the hypertriglyceridemic waist phenotypes was13.9%(109of785CKD patients) in this cohort of CKD patients. Patients in group1had significantly higher BMI, waist circumference, and weight than those in groups2and3(p<0.01). Additionally, patient BMI, waist circumference, and weight in group2were significantly higher than those of group3(p<0.01).The glomeruler filtration rate (GFR) of group3was significantly lower than that of groups1(p<0.05) and2(p<0.01).Triglyceride, total cholesterol, HDL-cholesterol, and LDL-cholesterol in group1were significantly higher than those in group3. Furthermore.carotid artery IMT of group1was higher than that of groups2(p<0.05) and3(p<0.01). GFR [>30ml/min, odds ratio=1.71(1.29,2.45), p<0.01], diabetes history [yes:1.58(1.10,2.26), p=0.01], and carotid artery IMT [>0.8mm,1.39(1.01,1.91), p=0.04] were statistically significant predictors of the hypertriglyceridemic waist phenotype.Conclusion:The hypertriglyceridemic waist phenotype was associated with worse carotid atherosclerosis in CKD patients. This suggests that the hypertriglyceridemic waist phenotype may be useful for predicting CVD risk in CKD patients. Objective：The incidence of abdominal obesity has steadily increased, while obesity is the risk factor which worsen the chronic kidney disease (CKD) patients and increased the incidence of cardiovascular morbidity and mortality in CKD patients. In this study, CKD patients as the research objects, lipid accumulation product (LAP) which could reflect abdominal obesity well as breakthrough point, to discuss the relationship between LAP and atherosclerosis.Methods:Collect the parameter of anthropometry like height, weight and waist circumference, clinical parameters including fasting blood lipid, carotid IMT, clinical history of778CKD patients, according to the formula:(WC-65)*TG (male) or (WC-58)*TG (female) to calculate the LAP, use single factor correlation analysis to analyse the partial correlation between carotid atherosclerosis and clinical and biochemical indexes, multiple regression analysis was used to identify predictors of carotid atherosclerosis.Results:In778CKD patients, single factor correlation analysis showed:the variables have correlation with carotid arteriosclerosis included:age, GFR, hemoglobin, uric acid, BM1, LAP. In these variables, age, uric acid, hemoglobin, BMI, LAP is positive correlated with carotid atherosclerosis, while GFR, hemoglobin was negative correlated with carotid atherosclerosis. Multivariate regression analysis showed:the predictors of carotid IMT including:age (P<0.01). history of hypertension (P<0.01), BMI (P<0.05), gender (P<0.01) and logLAP (P<0.05).In these variables, age, history of hypertension, BMI and logLAP have positive correlation with carotid artery IMT, while gender have negative correlation with carotid IMT.Conclusion:In patients with chronic kidney disease, LAP positively correlated with carotid IMT, showed that the incidence of atherosclerosis increase with the developing of LAP, LAP could be used as an effective predictor of cardiovascular risk in patients with CKD. |
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