The Effect Of Nosiheptide On Performance In Weaned Piglets And Growing-Finishing Pigs

Two experiments were conducted to study the effect of the different supplement level of nosiheptide on performance, residues in partial organs and tissues, intestinal bacteria population and intestinal mucosa form in weaned piglets and growing-finishing pigs.Experiment 1: 54 weaned crossbred (Yorkshire ×Landrace) piglets with 10kg initial body weight were randomly assigned to six groups, with three replicates of 3 piglets per group. All groups were provided with the same basal diets which only differed in nutritional antibiotcs, respectively Nosiheptide of low, middle and high level (5mg/kg,10mg/kg,20mg/kg), Salinomycin group (50mg/kg), compound group with Zinc bacitracin 40mg/kg+CoIistin sulphate 10mg/kg and the Control group (without nutritional antibiotcs). During the period of experiment, feed intake and healthy condition were recorded each day, and daily feed intake ,daily gain, feed/gain and the rate of diarrhea in piglets were calculated. At the end of experiment, three randomly selected piglets for each group were slaughtered, the contents in the middle of jejunum, ileum and colon were sampled for bacteria population, and the tissue in the middle of jejunum and ileum for intestinal mucosa form. The results showed that all levels of nosiheptide have the tendency to increase daily gain and decrease feed/gain and diarrhea. High nosiheptide group is the best on performance, but no significant difference among groups (p>0.05). Nosiheptide decreased significantly Bifidobacterium numbers of jejunum and ileum (p<0.05) , and had tendency to increase E.coli numbers in jejunum, ileum and colon. Middle and high level of nosiheptide groups decreased clostridium numbers of jejunum, ileum and colon (p<0.05) . All nosiheptide group had tendency to decrease intestinal wall thickness and crypt depth, increase villi length. High level of nosiheptide group increased ileum villi length and decrease ileum wall thickness significantly (p<0.05) .Experiment 2: 32 growing crossbred (Yorkshire×Landrace) pigs with 30kg initial body weight were randomly assigned to four groups, with eight replicates per group. All groups were provided with the same basal diets which only differed in nutritional antibiotcs, respectively Nosiheptide of low and high level (10mg/kg,50mg/kg), Salinomycin group (30mg/kg) and the Control group (without nutritional antibiotcs). Recorded daily feed intake, healthy condition and measured weekly weight. When weights were about 90kg, were slaughtered according to withdraw nosiheptide 0 days, 3 days and 7 days, measured dressing percent, back-fat thickness, area of longissimus dorsi, pork color, pH, drip-loss, shearing forceand intramuscular fat. Residues of nosiheptide were performed on heart, liver, kidney and longissimus dorsi muscle samples of 30 gram with High Performance Liquid Chromatography. The result showed that nosiheptide increased feed intake and daily gain of growing-finishing pigs significantly (p<0.05) ,feed intake and daily gain were respectively 2064.4 gram and 615.2 gram in high level of nosiheptide group, compared with the control group, they increased 10.25%( p<0.05) and 14.67%( p<0.05) respectively, but no different significantly on feed/gain among groups(p>0.05). There wasn't any adverse effect on characteristics and quality of carcass when added 10mg/kg and 50mg/kg nosiheptide to diet. When detection's sensitivity was 0.01mg/kg, result revealed no microbiologically active residues in heart, liver, kidney or longissimus dorsi muscle obtained from pigs given feeds supplemented with nosiheptide at 10mg/kg and 50mg/kg.