Effect Of Jinglei Jiedu Powder On The Residue Of Aflatoxin M _{1 In Milk Of Dairy Cow}

Contamination of aflatoxin in feed is the major problem of dairy hazards at the moment. To investigate the influence of aflatoxin M₁ residues in milk of dairy cows with feeding Jin-ge detoxification pulvis, 24 Holstein cows were selected and classified into six groups as A, B, C, D, E and F. Group A was control group with healthy cows fed with regular forage without pollution of aflatoxin（contents of aflatoxin B1<10ug/kg）. Among these 5 groups, fed with regular forage with pollution of aflatoxin（contents of aflatoxin B1>10ug/kg）, and cows in groups B, C and D were fed with Jin-ge detoxification pulvis at the same time and the additive amounts for each cow one day were 25 g, 50 g and 75 g. Cows in group E were fed with mycotoxin removement agent and the additive amounts were 1500mg/kg. Group F was a positive control group and cows in this group were treated without any veterinary drugs. Testing period lasted for three weeks. On the 1, 8 and 15 days, milk samples were collected to measure residual amounts of aflatoxin M₁. And jugular vein blood after 7, 14 and 21 days were collected to test biochemical indexes liver functionas as CHE, D-BIL, T-BIL, ALT, AST, ALP, GGT, ALB, TP, GST and antioxidant capacity as SOD, MDA and T-AOC.The result showed that, Jin-ge detoxification pulvis can significantly lower contents of D-BIL, T-BIL, ALT, AST, ALP, GGT, ALB and GST（P<0.05）, increase contents of CHE and TP（P<0.05）. There is no significant difference among groups A, D and E（P>0.05） with time-effect relation. Jin-ge detoxification pulvis can significantly lower contents of MDA（P<0.05）and increase contents of SOD and T-AOC（P<0.05）. There is no significant difference among groups A, D and E（P>0.05）, with time-effect relation. Jin-ge detoxification pulvis can significantly lower content of aflatoxin M₁ in milk of cows residues（P<0.05）, there is no significant difference among groups A, D and E（P>0.05）, with time-effect relation.In general, through strengthen liver function and antioxidant capacity of dairy cows, Jin-ge detoxification pulvis can reduce aflatoxin M₁ residues in milk of dairy cows.Have the effect of alleviate aflatoxin toxicity in feed.Furthermore,appropriate additive amounts for each cow are 75g/day.