Development And Experimental Research On Optical Coherence Tomograhy System

By combining some advantages of optical heterodyne detection and scanning tomography, optical coherence tomography (OCT) provides images with high sensitivity, high resolution in transverse and depth dimensions. It is a novel technique imaging from the scattering medium such as the creature tissue. Its non-invasive characteristic and ease of use in vivo promoted its rapidly development in recent years since it was brought forward several years ago. Fiber and some related produces get mature with development of telecom. Applied fiber produces to OCT, the whole system changes very compact and its low cost makes its wide application possible in clinical medicine. In this thesis, we studied the system design and application based on OCT imaging principle and method.Analyzed the OCT principle and the problems in previous OCT system of our laboratory, this thesis presented a plan to rebuild this system. The modified OCT system could image the tissue automatically and it has the advantages of high sensitivity and high capability-price-rate. The modified system is a low cost OCT system with optics, mechanics and electrics parts. The system used the SLD light source with wavelength of 1310nm and half width of 30nm, so the system has the resolution of 25 in longitude and 24μm in latitude. The hardware was built with double CPUs. The personal computer controlled the whole system conveniently and displayed the result in real time. The longitude scanner based on microcomputer reduced the relative error of scanning speed to one percent. So the scanning system was digitized and the stability and intelligence of the system is advanced, then the OCT system could be used in real time imaging of tissue sample. High quality images of standard and tissue samples obtained with the modified system. Comparing with previous and other foreign system, the results showed that the modified system could obtain tissue structure with high resolution and it has the advantages of high sensitivity, intelligence and non-invasive. Furthermore, as the performance of the system was optimized, the high capability-price-rate of this system would extend applications for the technique in experimental study and clinic of bioengineering detecting and imaging.