Research Of Biginelli Reaction And Hantzsch Reaction And Depressant Research Of Low Temperature Flow Improver Of Diesel Oil

Pyrimidone and dihydropyridine is important category of compounds including nitrogen which have applied values and biological activities. Many substituted pyrimidons are a broad highly active drug. Dihydropyrimidinones have broad therapeutic and pharmaceutical properties, as medical intermediate, which have antiviral, antitumour, antibacterial and anti-inflammatory activities, and have been used as potent calcium channel blockers, antihypertensive agents, adrenergic and neuropeptide Y (NPY) antagonist. Batzelladine A and B which are the first low molecular weight natural products reported in the literature to inhibit the binding of HIV gp-120 to CD4 cells, so disclosing a new field towards the development of AIDS therapy. 1,4-Dihydropyridines are analogy with Pyrimidones in the construction, which have expanding vascular, antihypertension, antiarteriosclerosis, antitumor, antimelituria and antifade activities. Many biologic alkalis including dihydropyridine have been used as perfect target of synthesis because of their specific construction and tremendous potentiality inhibited in medical field. Most of research groups have peoceeded a large quantity of studied in the method improvement of synthsis and in seek to leading molecules of drug with biological activity, but dihydropyrimidinones including 1,2,3-triazolyl were not reported. In order to find parent biological activity for new drugs, we designed and synthesized pyrimidone and dihydropyridine incorporating with bioactive 1,2,3-triazolyl in an effort to enhance their biological activity, a serise of desired triazolyl dihydropyrimidone compounds and 1,4-dihydropyridine compounds were obtained and seeked to an new catalyst of highly catalytic active. The structures of all the synthesized compounds were confirmed by analytical analysis and spectral data (IR, HNMR and MS).A low temperature flow improver (ASAMa) was synthesis by free radical copolymerization reaction of acrylate, styrene, acrylonitrile and maleric anhydride for Xinjiang high Wax content diesel. The influencing factors such as monomer ratio, mass fraction of initiator and solvent and reaction temperature on cold filter plugging point (CFPP) depressing effects were investigated by orthogonally designed experiments. The depressant was applied for 0# diesel fuels of Dushanzi refinery, the SP (solidifying point) of the 0# diesel fuel was lowered by 10℃and the CFPP (cold filter plugging point) 5℃.The major accomplishments of the thesis:1. A novel series of 3,4-dihydropyrimidin-2(1H)-(thio)ones including substituted triazolyl were synthesised by a one-pot three component cyclocondensation reaction with a 1,3-dicarbonyl compound or cyclopentanone, 2-phenyl-1,2,3-triazoly-4-formaldehyde and urea or thiourea (substituted thiourea) using Samarium perchlorate [Sm(ClO4)3] as an efficient catalyst.2. A novel series of 1,4-dihydropyridines including substituted triazolyl were synthesised by Hantzsch reaction with a 1,3-dicarbonyl compound, 2-phenyl-1,2,3-triazoly-4-formaldehyde and NH4Cl, and were partially aromatizated to pyridine using Samarium perchlorate [Sm(ClO4)3] as an efficient catalyst.3. First, acroleic esters and maleic esters were separately synthesised with corresponding alcohol (lauryl alcohol, tridecyl alcohol, hexadecyl alcohol, octadecanoic alcohol), then mixed with styrene and acrylon in some ratio and thermostatic reation under nitrogen protection. ASAMa polymer was obtained and proceeded cold flow testing against 0# diesel fuels of Dushanzi refinery.The major innovations of the thesis:1. Seeked to an new catalyst of highly catalytic active in application to Biginelli reaction and Hantzsch reaction.2. Only urea and thiourea were used in past Biginelli reaction, substituted thioureas were used in Biginelli reaction and continuated a field of thiourea.