| The health of human being has been harmed by cancer. People are seeking new medicine to defend and completely cure cancer. Lots of research works showed that dialkyltin compounds have obvious antitumour activity. In drug molecule whose certain C atom was substituted by a silicon atom was called silicon drug, the effect of the drug will be reserved and the toxicity be reduced. In order to study systemically the relation between structure and effect of organotin, three diorganotin nitrobenzatolates and threeorganotin phenanthroline complexes containing silicon were synthesized in this paper.Their structure were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR , X-ray diffraction. The results indicated that the Sn atom of all complexes is in a six-coordinated distorted octahedron.The preliminary bioassay tests showed that some complexes have a good antitumour activity in vitro against Hela and SPC-A-1 tumour cells.This preliminary research on a series of novel silicon-containing diorganotin compounds with biological activities may enrich the study of organotin chemistry, and provide scientific basis for the exploitation of high-safety and high-efficiency organotin organotin pharmaceuticals. |
