The Synthesis And Spectral Properties Of Diorganotin Hydroxamates Containing Silicon

It has been widely researched to the anticancer activities of Organotin (â…£) compounds since Brown first revealed that Ph3SnO2CCH3 could inhibit the growth of tumor in rats. Some organotins exhibit better antiproliferative properties in vitro than cisplatin used for clinical treatment. Numerous studies have shown that diorganotin containing silicon compounds has stronger anticancer activity. Based on the research above, this paper design and synthesize 9 diorganotin hydroxamates containing silicon compounds.(1) Four new diorganotin dihydroxamates containing silicon: (Me3SiCH2)2Sn{RC(O)NHO}2 (R=C6H5, p-ClC6H4, CH3CH2CH2, CH3CH2CH2CH2CH2)(2) Four new mixed diorganotin dihydroxamates containing silicon: R(Me3SiCH2)Sn{R'C(O)NHO}2 (R=Ph, Bu, Cy; R'=CH3CH2CH2, CH3CH2CH2CH2CH2)(3) One new diorganotin monohydroxamates containing silicon: {(Me3SiCH2)2SnC6H4C(O)NH}2OIn this paper, the synthesis method was optimized. The compound structure was characterized with IR,1H NMR,13C NMR spectrometer and elementary analysis, and the result showed that the compounds were O-O chelating compounds. the water-solubility was preliminarily tested.