Construction Of Drug-induced Toxicity Related Proteins Database

Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates, to a large extent, better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-Induced Toxicity Related Protein Database (DITOP) is such a database that is intending to provide comprehensive information of DITRPs. Currently, DITOP contains 1665 records, covering 653 distinct literature-reported DITRPs, 536 drugs/ligands, and 425 distinct toxicity terms. These proteins were confirmed experimentally to interact with drugs or their reactive metabolites, thus directly or indirectly cause adverse effects or toxicities. Five major types of drug-induced toxicities are included in DITOP, which are the idiosyncratic adverse drug reactions, the dose-dependent toxicities, the drug-drug interactions, the immune-mediated adverse drug effects (IMADEs) and the toxicities caused by genetic susceptibility. Molecular mechanisms underlying the toxicity and cross-links to related databases are also provided while available. Moreover, a series of user-friendly interfaces were designed for flexible retrieval of DITRPs-related information. DITOP will greatly facilitate the research on ADR and drug development.