Syndrome Characteristics And Chinese Medicine Intervention Clinical Research Of Coronary Heart Disease Combine With Depression

A high incidence of coronary artery disease with depression, Cause the medical profession intense attention. Coronary heart disease and depression between inner link, there is a certain. Two promote each other, forming a new disease characteristic. Traditional medicine with disease as the core, and treatment based on syndrome differentiation as the characteristic, with combined therapy of disease and syndrome, can achieve the best effect. This research from two aspects of theory and clinical research of coronary heart disease with depression, aims to explain its etiology and pathogenesis of TCM, to find its syndrome features. Legislation and prescription are based on its syndrome features. Observe clinical curative effect, reflect the legislation prescription medicine advantages and treatment of coronary heart disease with depression application prospect.1. The study of Coronary heart disease and depression's Characteristics of syndromesThis study used clinical epidemiology cross-sectional survey method of 100 cases of coronary heart disease with depression, study analyzed patients coronary depression syndrome features different age stages, angina pectoris parting different, merger disease, whether comorbid anxiety and so on different circumstance, and the main syndrome elements and syndrome elements combination, etc, and overall understanding of the disease and coronary depression syndrome features relationship.The results show:From the age of subsection syndromes element characteristic looking, change with age, syndrome elements have different characteristics. Main show:1) 49-60 patients, syndrome factor proportion is the first three gan yu, and qi zhi, Yin xu. In this life stage, Yin and Yang appear attenuation change, also Yin and Yang self adjusting stage, Also easy incidence stage.2) 60 years later, Yin and Yang attenuation rate reaches relative stable state, the adjustment period has their own after regulation by the human body to achieve another stage of the steady-state phase of low. By age, gradually alleviate gan yu and kidney empty, qi deficiency of increasing gradually obvious, a variety of reasons, the blood did not free, blood stasis formation, therefore, blood stasis highlights, syndrome factor proportion appear changes.Different, coronary heart disease, angina classification feature has different syndromes, unstable angina patients qi debility, blood stasis, kidney empty, tan zhuo and Yang xu obviously higher than the distribution proportion syndrome, chronic stable angina syndrome elements species than patients with stable angina, from the syndrome elements combination also complicated.This study patients with coronary depression syndrome elements is included as follows:blood stasis, and qi deficiency of the kidney deficiency, ganyu, Yin deficiency, tanzhuo, and qi stagnation, Yangxu, spleen deficiency, hot accumulate, HanNing. Frequency above 50% is blood stasis, ganyu, kidney deficiency, Yin deficiency. Its combination with four elements combination, followed by six elements combination, once again, is five elements combination, is three elements, seven elements, eight elements, two elements.2. Traditional Chinese medicine clinical research of coronary depression interventionWith coronary depression syndrome features as the foundation, Establish yi qi yangyin huoxue, yangxin anshen bushen,ShuGan yanggan huatan method, ShengMaiYin, Prescription ShengMaiYin, danshen yin, gualouxiebaibanxiatang and jiaweisinisan, patients with coronary depression, clinical randomized controlled trials, Chinese medicine intervention group above party plus isosorbide mononitrate, western medicine control group isosorbide mononitrate and add fluoxetine, clinical observation 71 cases of coronary heart disease with depression, the results are as follows:2.1 Clinical curative effectTraditional Chinese medicine intervention would not only ease angina symptoms, also can improve patients' systemic other symptoms of Sweat out anomalies, sleep abnormalities, such as abnormal, abdominal distension feeling unwell and self with their daily life, improve symptoms of good, relieves patients daily pain.2.2 Biological indicators and action mechanismTraditional Chinese medicine can reduce blood HSCRP intervention, IL-6 level, and HSCRP, and improve NE. Chinese medicine therapy in improving syndrome coronary depression, but also on the inflammatory response to play the role of inhibition. It also can speculate that one of its mechanisms is inhibit the inflammation. Traditional Chinese medicine intervention group after treatment, NE than before treatment, the TCM intervention elevated NE function. Bushen can improve the kidney function, through bushen increases patient NE function, may also be Chinese medicine intervention mechanism of coronary depression.2.3 Drug prescription aspectsPrescription from syndromes, syndrome from disease, prescription with disease and syndrome unifies, is always BianZhengLun zhi of the TCM's principle. This study from disease characteristics and syndrome characteristics unifies, legislative prescription. Prescription:ShengMaiYin, Danshenyin, Gualouxiebaibanxiatang and Jiaweisinisan. Drug efficacy combination Drug clinical pharmacology, reasonable formula, achieves all-round, multi-level targets, more treatment. Clinical curative effect of traditional Chinese medicine intervention, according to significantly better than western medicine treatment, reflects the advantage of TCM treatment.