Explore Study On "Pungent" Of Radix Glehniae Based On Pharmaphylogeny

Chinese material medicine theory is the study medicinal forming mechanism of medicinal use regular theory, and is the most important academic feature of science of Chinese pharmacology. Material medicine includes the foundation of drug play curative effects and the functions that present during the process. Generally thinking, material medicine theory includes four properties, five flavours, ascending descending sinking floating, channel tropism, poisonous non-poisonous, compatibility of medicines, tabu and so on, and four properties, five flavours is the key. With modern scientific ways and technological methods studying Chinese material medicine, revealing scientific reason is the objective requirement of self-innovation of Traditional Chinese Medicine.Medicinal material (medicinal slice) is the carrier of drug, chemical composition is the material basis of drug property pharmacology, revealing the related regularity of nature of Chinese materia medica-pharmaco-effect-chemical composition is the key of stating Chinese material medicine connotation. Hence, in this paper, we propose the thinking of research on nature of Chinese material medicine in view of genetic relationship.We carry out the relevant analysis and research with pungent herbs' Chemical constituents being the representative.On the basis, I state Chinese material medicine composition and its forming methods.The main study concept includes:1 Resemble-thinking——the thinking way of formation of nature of Chinese materia medicaIn order to have a better understanding of formation of nature of Chinese materia medica and its scientific implications, we state the resemble-thinking which is the main thinking way of formation of nature of Chinese materia medica.In the theory of traditional Chinese medicine medicinal pointed out that four gas by lifting to tastes as in past dynasties efficacy of its clinical medical practice basis.Through like thinking methods to summarized, including that all aspects of like thinking are specific application.The establishment of the theory of traditional Chinese medicine medicinal, on one hand, it's in relation to the practical test of life phenomenon and medicinal herb, on the other hand, it has a deep influence on traditional resemble-thinking.During the process of studying Chinese materia medica, by the way of contrast, as for the tool, with external elephant, according to the drugs and the earth natural gas as, like four natures associated ups so as to lift, doctors classify and mark the common characteristic and nature of Chinese medicine, so that we can reach the goal of knowing and applying Chinese medicine.Still, the deep effects of resemble-thinking bring inspirations to modern research.2 Analogy88——relationship along plant taxonomy, Pharmaphylogeny and Nature of Chinese materia medicaIn this paper, we overviewed the plant taxonomy, Pharmaphylogeny and Nature of Chinese materia medica, analysised the way of recognition respectively. Resemble-thinking is the implement of recognition and discovering the drugs in TCM. Pharmaphylogeny is the theory and method of discovering the drugs and resources contemporary. Plant taxonomy is the theory of plant recognition and identification, and is the base of Pharmaphylogeny, also is the biology base of Nature of Chinese materia medica.They reconstruct the morphological trait of plant (medicinal plant), and induce the commonness regularity according to the same or similar traits.3 Intersect——study on nature of Chinese material medicine in view of genetic relationship.In this paper, proposing the thinking of research on nature of Chinese material medicine in view of genetic relationship, namely, according to the cue of documents arrangement and data excavation, in certern scope of genetic relationship, difinite the common pharmaco-effect of the same nature of drug, and analyze the chemical composition correlated the nature of drug, further more, reveal the related regularity of nature of Chinese materia medica-pharmaco-effect-chemical composition.Then combine Chinese material medicine, pharmaco-effect, chemical composition, it offers new ideas when it comes to the status quo of research on nature of Chinese materia medica.4 Practice——The relevant study of Umbrelliferae Chinese medicine "pungent-chemical -bioactivity"According to the thinking of research on natureof Chinese material medicine in view of genetic relationship, I regard Umbrelliferae Chinese medicine as representation, pungent herbs as entry point, conducting umbrelliferae traditional Chinese medicine the commonness of efficacy and biological effects of relevance analysis research.The majority of common Chinese medicines of Umbrelliferae have pungent herbs, it can stop pain or promote blood circulation.According to the theory of pharmaphylogeny, and combining modern pharmacology experimental results and preliminary studies, it suggests that to vasodilation role of observation index, the main chemical composition of Umbrelliferae Chinese medicine pungent herbs-chemical composition has the function of better vasodilation activity5 Explore——the explore and experiment study on "pungent" of Radix GlehniaeRadix Glehniae derives from the root of Coral cuisine. Family umbelliferae plant Glehnia littoralis Fr. Schmidt ex Miq, and some chemical compositions are similar with Radix Angelicae, but in ancient books of materia medica straight ladybell has no north-south part, in common it's ladybell. In order to have a better knowledge of Radix Glehniae' function and pharmacological action, in this paper, we make the similar analysis of Radix Glehniae, Radix Adenophorae, Radix Angelicae. Based on the three water frying liquid chromatographic mass spectrometry analysis, you can find that a dahurica ingredients in Radix Glehniae were peak and its peak area proportion than in the Radix Adenophorae ingredients common peak and its peak area ratio of the north, and verifies the chemical composition and a. dahurica straight ladybell is more similarities.Further combining modern research among the reports in the literature and the results of the study, north sand common ingredients in a. dahurica contains Isoimperatorin and Imperatorin has very good blood vessels to activity, to the extent it reflects pungent herbs' function characteristics of working and spreading. Based on this, according to, this experiment tests the analgesic effect of north of liquid water frying straight ladybell, compared the Radix Adenophorae and water straight ladybell a. dahurica north of extractings from chemical stimulus law made mode (superthreshold the improving function of pain model).As the result reflects, Radix Glehniae and Radix Angelicae can significantly reduce the glacial acetic acid in mice caused body torsion of The Times, and the suppression rate of The Times is quite, it shows certain analgesic action, and presents a similar pharmacological effect, but Radix Adenophorae can't reach this goal. Therefore, it further proves that Radix Glehniae has pungent, and umbrelliferae essien general efficacy namely analgesic effect.6 Promote——Concept, scientific implications of nature of Chinese materia medicaIn the above ideas and practical basis, through the literature pectination and modern related knowledge, the concept and the form of medicinal scientific content for a thorough explanation.Nature of Chinese materia medica, namely attribute of Chinese materia medica, including the natural attribute and the effective attribute, is formed by inheriting the physical environment factors, adjusting the organism states, using in clinical easily, and summarizing through the methods of Chinese philosophy. If we have a correct unders tanding of traditional Chinese medicine medicinal nature and two aspects, and its effect attributes forming process, it can help to strengthen the relevance of two attributes, and makes the research on nature of Chinese materia medica into a organic integrity.The chemical constituents from natural attributes of biological effects effect attributes of Chinese association rule reveals the internal quality anesthesiologists.This paper summarized the process of Chinese medicine medicinal properties, pungent herbs theory, Radix Glehniae, proposing the thinking of research on nature of Chinese material medicine in view of genetic relationship, regarding Umbrelliferae Chinese medicine as representation, pungent as entry point, conducting umbrelliferae traditional Chinese medicine the commonness of efficacy and biological effects of relevance analysis research, so the thinking and practice further found with essien straight ladybell TCM north, and verifying with the comparison between chemical composition and pharmaco-effect of Radix Glehniae, Radix Angelicae, Radix Adenophorae. On this basis, and it has important guiding significance to clear the research content of Chinese medicinal properties, expand research direction of Chinese medicinal properties of Chinese medicinal properties and carry out comprehensive modern research.