| Drug-resistant bacterial infections and malignant tumors are some of the major diseases that seriously affect human health and threaten human life,posing a huge public health problem worldwide.Therefore,metal boron imidazolate frameworks(BIFs)are the most intriguing new developments that play important roles for disease diagnosis and treatment due to their unique characteristics such as novel and diverse structures,adjustable porosity,and good biocompatibility.However,there are several problems,such as too specific function of BIFs,and insensitive response of bacteria or tumor microenvironment,which limit their wide application.To address these problems,this study proposed the construction of BIFs—based composites and design integration mechanisms,utilizing the synergy effect of different components to effectively improve the antibacterial and anticancer performance.Further,the antibacterial and anticancer mechanisms are revealed and discussed.The main research contents are summarized as follows:(1)Metal nanoparticles@Zn(II)boron imidazolate frameworks(M-NPs@Zn-BIF)composites were successfully in situ synthesized using the reducing ability of the B—H bond contained in Zn-BIF without any additional chemical reduction reagents.This study developed a simple and versatlile integrated platform for the effective inactivation of bacteria in water and the removal of nitrophenols.By adjusting the addition of auxiliary reagents in the synthesis process,Zn—BIF with exposed different crystal planes was synthesized.The antibacterial performance of M-NPs@Zn-BIF was examined by a fluorescent double staining method.an agar plate colony-counting method,and a growth curve method,and then the potential mechanism of the production of reactive oxygen species was revealed.Furthermore.using the nitrophenol reduction as a reaction model,the catalytic kinetics of M-NPs@Zn-BIF were analyzed,and the related mechanism was revealed.(2)A modified thermal decomposition method combined with a seed-mediated shell selfassembly growth technique was used to prepare gadolinium ion doped bismuth sulfide@Cu(?)boron imidazolate frameworks(Bi2S3:Gd@Cu-BIF)nanoassemblies as a theranostic nanoplatform to promote healing of wounds infected by methicillin-resistant Staphylococcus aureus(MRSA).Bi2S3:Gd@Cu-BIF nanoassemblies not only showed exceptional photothermal conversion,but also produced cytotoxic reactive oxygen species.Bi2S3:Gd@CuBIF nanoassemblies can effectively and safely kill growing and persistent MRSA.Particularly,in vivo skin wound healing experiments confirmed that Bi2S3:Gd@Cu-BIF nanoassemblies can accelerate healing following MRSA infections and the mechanism has also been proposed.Furthermore,the mechanism of Bi2S3:Gd@Cu-BIF nanoassemblies-mediated magnetic resonance imaging and computed tomography dual-modal imaging was explored through MRSA-infected subcutaneous abscess.(3)A modified thermal decomposition method combined with a seed-mediated shell selfassembly growth technique was used to prepare upconversion nanoparticles@Cu(?)boron imidazolate frameworks(CSNPs@Cu-BIF)nanoassemblies.The CSNPs@Cu-BIF nanoassemblies yield remarkable anti-breast cancer efficacy via photothermal/photodynamic/chemodynamic combination therapy under near-infrared(NIR)laser irradiation.The NIR light-triggered in situ generation of heat and reactive oxygen radicals by Cu+/Cu2+redox pair could cause the initiation of an intrinsic apoptotic pathway leading to amplified therapeutic efficacy.Multiclinical imaging modalities of ultrasonography are employed to investigate the ablation mechanism of solid tumors in vivo.Moreover,CSNPs@Cu-BIF nanoassemblies combine the precise fluorescent intensity ratio temperature control technology with the NIR laser activation technology to provide an alternative strategy for next-generation cancer therapy. |
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