Application Of MXene And BG Functional Nanofibers In The Treatment Of Skin Cancer And Postoperative Wound Repai

Skin cancer is usually treated clinically by surgical excision.However,unavoidable residual cancer cells and possible wound infection can lead to high tumor recurrence rates and slow wound recovery.Therefore,it is of great significance to develop an ideal treatment to inhibit the recurrence of residual tumors and accelerate the healing of broken tissues around the wound,which is of great significance for achieving the complete removal of residual cancer cells and postoperative skin regeneration.Two-dimensional nanofiber membranes have a structure similar to the extracellular matrix,which can not only play the role of physically blocking bacteria,but also can be combined with nanomaterials with excellent biocompatibility,and are widely used as wound dressings.Therefore,the specific work carried out in this paper is as follows:（1）MXene（Ti₃C₂T_x）with high efficiency photothermal conversion efficiency is combined with nanofibers prepared by electrospinning technology.The micro-nano effect was used to produce a similar lens effect,and the heat generated on the front side of the material was effectively conducted and concentrated to the back of the fibrous membrane through thermal management control,which ablated the residual melanoma cells and successfully inhibited the recurrence of residual tumors after surgery.The heat distribution and improvement were explained by Comsol simulation,and the photothermal conversion efficiency of the material was calculated to reach 40%.In addition,in vitro experiments have found that the material can effectively kill 98%of drug-resistant bacteria,and this highly effective bactericidal property can promote the healing of wound tissue after surgery（the healing time is shortened from 22 days to 16 days）.（2）Inorganic nanofibers（PG@BG）were synthesized by using solution blow spinning technology by loading 45S5 bioactive glass（BG）with different concentrations into PLA/GEL nanofibers.Through in vitro biocompatibility and CCk-8 experiments,it was found that the introduction of BG not only improved the cell affinity of PG@BG nanofibers,but also promoted the proliferation of fibroblasts on the fiber membrane.In addition,we placed fiber membranes containing different concentrations of BG at the wound site of rats,and in vivo experiments further demonstrated that PG@BG nanofibers accelerated the speed of wound repair.In summary,this paper uses electrospinning technology and solution blow spinning technology to realize the loading of two kinds of bioactive materials on the fiber membrane,showing excellent antibacterial properties and promoting tissue regeneration.It not only effectively inhibits the recurrence of postoperative melanoma,but also promotes the rapid healing of skin wounds.The feasibility and effectiveness of multifunctional composite fiber membrane as a dressing for the treatment of skin tumors were confirmed.