| Human exposure to hexachlorobenzene (HCB) has resulted in demineralization of bone resulting in osteoporosis. Experiments were undertaken to investigate the effects of HCB on the homeostatic mechanism of calcium metabolism and determine its effects on bone development. Fischer 344 rats were dosed with 0, 0.1, 1.0, 10.0 or 25.0 mg HCB/kg body weight 5 days/week for 5 weeks while being fed normal rat diet or vitamin D... |
