| We reviewed medical records of 704 patients with noninsulin dependent diabetes mellitus (NIDDM), who were admitted to the University of Michigan Hospital between 1978 and 1987. Data were analysed for 517 patients for whom complete information was available.;Diabetic nephropathy was defined by persistent proteinuria (;To assess the role of risk factors in determining the risk for nephropathy in NIDDM, we performed a case-control study in 189 subjects. Comparisons were made between 80 cases with diabetic nephropathy, 72 controls with normal urine protein levels (;Data were collected by medical chart abstracting, and by written questionnaires. Using logistic regression models, the risk for nephropathy was found to be associated with duration of diabetes of 15 years or more (O.R. ;Nephropathy was also found to be significantly associated with above normal levels of triglycerides (;We concluded that duration of diabetes, poor glycemic control and poorly controlled blood pressure are important predictors for the risk of developing nephropathy in NIDDM. |
